Dynamic reconfiguration of human brain functional networks through neurofeedback
Dynamic reconfiguration of human brain functional networks through neurofeedback
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DOI：
10.1016/j.neuroimage.2013.05.019
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发表时间：
2013-11-01
期刊：
影响因子：
5.7
通讯作者：
Van De Ville, Dimitri
中科院分区：
文献类型：
--
作者：
Haller, Sven;Kopel, Rotem;Van De Ville, Dimitri
最近的fMRI研究表明，功能连接在认知任务（例如，学习）或由于各种神经系统疾病。我们测试了基于fMRI的实时神经反馈是否可以成为自愿重新配置大脑网络交互的工具。为了将学习相关效应与调节相关效应区分开来，我们首先训练参与者自愿调节听觉皮层的活动（训练阶段），随后要求参与者在没有反馈的情况下发挥习得的自愿自我调节能力（没有学习的转移阶段）。使用独立分量分析（伊卡），我们发现网络重新配置在听觉目标区域和（I）听觉通路之间的神经反馈训练阶段期间，（2）与视觉反馈加工相关的视觉区域;（3）与内省和自我调节相关的视觉区域;（4）与认知努力相关的工作记忆和高水平视觉注意区域。有趣的是，听觉目标区域被确定为重新配置的功能网络的枢纽，没有先验假设。在转移阶段，我们再次发现了听觉和注意网络之间的特定功能连接重构，证实了自我调节对功能连接的特定影响。与工作记忆相关的网络的功能连接不再改变，与工作记忆的缺席需求一致。我们证明，神经反馈学习是由功能连接的广泛变化介导的。相比之下，应用学习的自我调节涉及听觉设置中更有限和具体的网络变化，旨在作为耳鸣的模型。因此，神经反馈训练可以用来促进与大脑连接异常模式有关的神经系统疾病的恢复。(C)2013 Elsevier Inc. All rights reserved.
Recent fMRI studies demonstrated that functional connectivity is altered following cognitive tasks (e.g., learning) or due to various neurological disorders. We tested whether real-time fMRI-based neurofeedback can be a tool to voluntarily reconfigure brain network interactions. To disentangle learning-related from regulation-related effects, we first trained participants to voluntarily regulate activity in the auditory cortex (training phase) and subsequently asked participants to exert learned voluntary self-regulation in the-absence of feedback (transfer phase without learning).Using independent component analysis (ICA), we found network reconfigurations (increases in functional network connectivity) during the neurofeedback training phase between the auditory target region and (I) the auditory pathway; (2) visual regions related to visual feedback processing; (3) insula related to introspection and self-regulation and (4) working memory and high-level visual attention areas related to cognitive effort. Interestingly, the auditory target region was identified as the hub of the reconfigured functional networks without a-priori assumptions. During the transfer phase, we again found specific functional connectivity reconfiguration between auditory and attention network confirming the specific effect of self-regulation on functional connectivity. Functional connectivity to working memory related networks was no longer altered consistent with the absent demand on working memory.We demonstrate that neurofeedback learning is mediated by widespread changes in functional connectivity. In contrast, applying learned self-regulation involves more limited and specific network changes in an auditory setup intended as a model for tinnitus. Hence, neurofeedback training might be used to promote recovery from neurological disorders that are linked to abnormal patterns of brain connectivity. (C) 2013 Elsevier Inc. All rights reserved.