Is perinatal depression familial?
Is perinatal depression familial?
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DOI：
10.1016/j.jad.2005.10.006
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发表时间：
2006-01-01
影响因子：
6.6
通讯作者：
Levison, DF
中科院分区：
文献类型：
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作者：
Murphy-Eberenz, K;Zandi, PP;Levison, DF
背景：虽然重度抑郁障碍（MDD）是家族性的，但尚不清楚不同的家族遗传因素是否会影响怀孕期间或怀孕后的抑郁易感性。在这里，我们研究了来自复发性早发性抑郁症遗传学数据集的多例复发性早发性重度抑郁症（PND，妊娠期间或分娩后一个月的任何发作）和产后抑郁症（PPD）家庭中围产期重度抑郁症（PND）的家族聚集性。方法：数据集包括691名可归类为PND（27.6%）或非PND （NPND）的育龄妇女，其中328名是148名兄弟姐妹中两名或两名以上PND或NPND的成员。比较PND和NPND受试者在假定预测因素上的差异。先证者病史对兄弟姐妹PND或PPD的预测采用逻辑回归和一般估计方程方法进行检验。结果：PND的发作次数较少，当前年龄较小。预测兄弟姐妹身份的比值比对于PND（2.28）和PPD（3.96）具有显著意义，特别是当当前年龄低于46岁时（分别为2.87和4.39）。PPD的or与PND的or无显著差异。将当前年龄作为协变量引入模型后，PPD的OR（3.52）仍然显著，而PND的OR（3.52）则不显著，但当模型中同时包括当前年龄和发作次数时，OR就不显著了。局限性：由于没有收集所有妊娠的详细数据，我们无法确定当前年龄和发作次数是否由于回忆偏倚或其他因素（队列效应、发作次数）介导了观察到的影响。结论：结果提示PND，特别是PPD的家族性成分。然而，需要更系统的研究来证实这一结果。对遗传和非遗传家族性因素的更深入了解可以改善预防和临床管理。(c) 2005 Elsevier B.V.版权所有
Background: While major depressive disorder (MDD) is familial, it is not clear whether distinct familial-genetic factors influence vulnerability to depression during or after pregnancy. Here we examine familial aggregation of perinatal major depression (PND, any episode during pregnancy or the month after childbirth) and the subset of post-partum depression (PPD) in families with multiple cases of recurrent, early-onset MDD from the Genetics of Recurrent Early-Onset Depression dataset.Methods: The dataset included 691 childbearing women who could be classified as PND (27.6%) or non-PND (NPND), of whom 328 were members of 148 sibships with two or more PND or NPND women. PND and NPND subjects were compared for differences in putative predictors. Prediction of sibling PND or PPD by the proband's history was examined using logistic regression and general estimating equation methods.Results: PND was associated with fewer episodes and younger current age. Odds ratios for prediction of sibling status were significant for PND (2.28) and PPD (3.96), particularly when current age was under 46 (2.87 and 4.39, respectively). ORs for PPD were not significantly different from those for PND. The OR for PPD (3.52), but not for PND, remained significant after current age was introduced as a covariate, but not when both current age and number of episodes were included in the model. Limitations: Because detailed data were not collected for all pregnancies, we cannot determine whether current age and number of episodes mediated the observed effects due to recall bias or other factors (cohort effect, number of episodes).Conclusions: A familial component to PND, and particularly PPD, is suggested by the results. However more systematic study is needed to confirm this result. A greater understanding of both genetic and non-genetic familial factors could lead to improved prevention and clinical management. (c) 2005 Elsevier B.V. All rights reserved.