Nickel-catalyzed dehydrogenative cross-coupling: direct transformation of aldehydes into esters and amides.
Nickel-catalyzed dehydrogenative cross-coupling: direct transformation of aldehydes into esters and amides.
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DOI：
10.1002/anie.201410322
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发表时间：
2015-01-19
期刊：
影响因子：
--
通讯作者：
Dong VM
中科院分区：
文献类型：
--
作者：
Whittaker AM;Dong VM
通过探索一种新的镍催化交叉偶联模式，我们开发了一种将芳香族和脂肪族醛直接转化为酯或酰胺的方法。这种氧化偶联的成功取决于催化剂和有机氧化剂的适当选择，包括使用α，α，α-三氟苯乙酮或过量的醛。我们目前的机械数据，支持涉及氧化加成到醛C-H键的催化循环。
By exploring a new mode of Ni-catalyzed cross-coupling, we have developed a protocol to transform both aromatic and aliphatic aldehydes into either esters or amides directly. The success of this oxidative coupling depends on the appropriate choice of catalyst and organic oxidant, including the use of either α,α,α-trifluoroacetophenone or excess aldehyde. We present mechanistic data that supports a catalytic cycle involving oxidative addition into the aldehyde C–H bond.