Targeting the tumor microenvironment
Targeting the tumor microenvironment
复制标题
DOI：
10.2741/2327
复制
发表时间：
2007-05-01
影响因子：
3.1
通讯作者：
Bissell, Mina J.
中科院分区：
文献类型：
--
作者：
Kenny, Paraic A.;Lee, Genee Y.;Bissell, Mina J.
尽管取得了一些显着的成功，但癌症在很大程度上仍然是一个看似棘手的问题。然而，人们越来越认识到，孤立地靶向肿瘤上皮是不够的，因为肿瘤上皮细胞与其周围基质之间存在复杂的相互维持的协同作用。随着对话细节的浮出水面，新的治疗目标也被提出。 FDA 已经批准了针对 VEGF 和芳香酶等微环境成分的药物，还有更多药物正在研发中。在本文中，我们描述了肿瘤微环境中的一些“可成药”靶点和过程，并回顾了破坏这些相互作用所采取的方法。
Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the "druggable" targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.