The LDL receptor.
The LDL receptor.
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DOI：
10.1161/atvbaha.108.179564
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
Brown MS
中科院分区：
文献类型：
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作者：
Goldstein JL;Brown MS
在这篇文章中，低密度脂蛋白受体的历史由它的共同发现者讲述。他们早期对低密度脂蛋白受体的研究解释了心脏病发作的遗传原因，并导致了对胆固醇新陈代谢的新思维方式。低密度脂蛋白受体的发现还引入了细胞生物学的三个一般概念：受体介导的内吞作用、受体循环和受体的反馈调节。后一种概念提供了他汀类药物选择性降低血浆低密度脂蛋白、减少心脏病发作和延长生命的机制。
In this article, the history of the LDL receptor is recounted by its co-discoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors. The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.