Granulocyte transfusions in the management of invasive fungal infections.
Granulocyte transfusions in the management of invasive fungal infections.
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DOI：
10.1111/bjh.14597
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发表时间：
2017-05
影响因子：
6.5
通讯作者：
Kadri SS
中科院分区：
文献类型：
--
作者：
West KA;Gea-Banacloche J;Stroncek D;Kadri SS
粒细胞输注用于中性粒细胞减少或中性粒细胞功能障碍患者预防和治疗侵袭性真菌感染的历史悠久。然而，关于其临床有效性的数据有限且相互矛盾，当前粒细胞输注实践存在相当大的差异，并且其作为现代抗真菌治疗的辅助治疗的益处存在不确定性。在这篇综述中，我们提供了一个概述粒细胞输注和总结的证据，其作用的预防和治疗侵袭性真菌感染。
Granulocyte transfusions have a long history of being used in patients with neutropenia or neutrophil dysfunction to prevent and treat invasive fungal infections. However, there are limited and conflicting data concerning its clinical effectiveness, considerable variations in current granulocyte transfusion practices, and uncertainties about its benefit as an adjunct to modern antifungal therapy. In this review, we provide an overview on granulocyte transfusions and summarize the evidence on their role in the prevention and treatment of invasive fungal infections.