Role of Interleukin 1 in Atopic Dermatitis
Role of Interleukin 1 in Atopic Dermatitis
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DOI：
10.1016/j.det.2013.04.008
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发表时间：
2013-07-01
影响因子：
2.4
通讯作者：
Valdecantos, Wendell C.
中科院分区：
文献类型：
--
作者：
Abramovits, William;Bejarano, Joaquin J. Rivas;Valdecantos, Wendell C.
白细胞介素-1（IL-1）是一种有效的炎性细胞因子，在先天性免疫应答中发挥核心作用。IL-1通过诱导局部和全身反应，如疼痛敏感性、发热、血管舒张和低血压来介导炎症的急性期。它还促进内皮细胞上粘附分子的表达，这允许炎性和免疫活性细胞浸润到组织中。活化后从表皮释放IL-1是通过诱导各种细胞因子、促炎介质和粘附分子促进炎性皮肤病症的主要事件。
Interleukin-1 (IL-1) is a potent inflammatory cytokine that plays a central role in the innate immune response. IL-1 mediates the acute phase of inflammation by inducing local and systemic responses, such as pain sensitivity, fever, vasodilation, and hypotension. It also promotes the expression of adhesion molecules on endothelial cells, which allows the infiltration of inflammatory and immunocompetent cells into the tissues. The release of IL-1 from the epidermis after activation is a primary event that promotes inflammatory skin conditions through the induction of various cytokines, proinflammatory mediators, and adhesion molecules.