Incremental rate of prefrontal oxygenation determines performance speed during cognitive Stroop test: the effect of ageing
Incremental rate of prefrontal oxygenation determines performance speed during cognitive Stroop test: the effect of ageing
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DOI：
10.1007/s12576-018-0599-3
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发表时间：
2018-11-01
影响因子：
2.3
通讯作者：
Matsukawa, Kanji
中科院分区：
文献类型：
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作者：
Endo, Kana;Liang, Nan;Matsukawa, Kanji
认知功能随着年龄的增长而下降。然而，导致认知能力下降的根本机制仍然知之甚少。我们假设，认知斯特鲁普测试期间前额叶氧合的增量速率随着衰老的进展而降低，导致认知能力下降。为了验证这一假设，我们使用多通道近红外光谱仪确定了前额叶皮层对不一致的斯特鲁普和一致的单词阅读测试的氧合血红蛋白浓度（Oxy-Hb）响应的特征。比较年轻和老年受试者之间氧-血红蛋白反应的三个组成部分（初始斜率、峰值振幅和曲线下面积）显着变化的空间分布。与年轻受试者相比，老年人的斯特鲁普干扰时间（分别作为执行斯特鲁普和单词阅读测试的总时间的差异）大约增加了一倍。在斯特鲁普测试中，两个年龄组的前额叶皮质中的氧合血红蛋白（Oxy-Hb）均有所增加，而尾侧前额皮质则没有增加。氧-血红蛋白反应的初始斜率，而不是曲线下的峰值和面积，与认知表现速度有很强的相关性。总而言之，随着年龄的增长，前额叶氧合的增量可能会降低，从而导致认知能力下降。
Cognitive function declines with age. The underlying mechanisms responsible for the deterioration of cognitive performance, however, remain poorly understood. We hypothesized that an incremental rate of prefrontal oxygenation during a cognitive Stroop test decreases in progress of ageing, resulting in a slowdown of cognitive performance. To test this hypothesis, we identified, using multichannel near-infrared spectroscopy, the characteristics of the oxygenated-hemoglobin concentration (Oxy-Hb) responses of the prefrontal cortex to both incongruent Stroop and congruent word-reading test. Spatial distributions of the significant changes in the three components (initial slope, peak amplitude, and area under the curve) of the Oxy-Hb response were compared between young and elderly subjects. The Stroop interference time (as a difference in total periods for executing Stroop and word-reading test, respectively) approximately doubled in elderly as compared to young subjects. The Oxy-Hb in the rostrolateral, but not caudal, prefrontal cortex increased during the Stroop test in both age groups. The initial slope of the Oxy-Hb response, rather than the peak and area under the curve, had a strong correlation with cognitive performance speed. Taken together, it is likely that the incremental rate of prefrontal oxygenation may decrease in progress of ageing, resulting in a decline in cognitive performance.