Stress and body mass index each contributes independently to tumor necrosis factor-alpha production in prepubescent Latino children.
Stress and body mass index each contributes independently to tumor necrosis factor-alpha production in prepubescent Latino children.
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DOI：
10.1016/j.pedn.2008.02.034
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发表时间：
2009-10-01
期刊：
影响因子：
--
通讯作者：
Delamater, Alan
中科院分区：
文献类型：
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作者：
Dixon, Denise;Meng, Hongdao;Delamater, Alan
这项研究扩展了先前的工作，确定压力和体重指数（BMI）是否独立地影响了青春期前拉丁裔儿童的肿瘤坏死因子-α（TNF-α）水平，以及性别和2型糖尿病（T2 DM）家族史是否改变了这些关系。数据收集自南佛罗里达的112名非糖尿病学龄西班牙裔儿童，其中43.8%为肥胖（BMI >/=第95百分位数），51.8%有T2 DM家族史。压力性生活事件通过父母报告使用生活事件量表进行评估。采用酶联免疫吸附试验测定血浆TNF-α水平。采用多元线性回归分析压力和BMI对TNF-α水平的相对贡献以及性别和T2 DM家族史的潜在交互作用。压力和BMI各自占与TNF-α相关的独特方差的显著比例。压力和TNF-α之间的关联并不受性别或T2 DM家族史的影响。这些发现暗示BMI和压力是拉丁裔儿童TNF-α（一种炎症细胞因子和脂肪细胞因子）的独立决定因素。未来的研究应该检查运动，营养状况，年龄和生长激素在解释TNF-α的产生和心理社会困扰之间的关系和肥胖儿童感染的风险的潜在作用。
This investigation extended prior work by determining if stress and body mass index (BMI) contributed independently to tumor necrosis factor-alpha (TNF-alpha) levels among prepubescent Latino children and if sex and family history of type 2 diabetes mellitus (T2DM) modified these relationships. Data were collected in South Florida from 112 nondiabetic school-aged Hispanic children, of whom 43.8% were obese (BMI >/= 95th percentile) and 51.8% presented with a family history of T2DM. Stressful life events were assessed via parental report using a life events scale. Plasma TNF-alpha levels were determined with enzyme-linked immunosorbent assay. The relative contributions of stress and BMI with TNF-alpha levels and the potential interaction effects of sex and family history of T2DM were analyzed with multiple linear regression analyses. Stress and BMI each accounted for a significant proportion of the unique variance associated with TNF-alpha. The association between stress and TNF-alpha was not modified by sex or family history of T2DM. These findings implicate BMI and stress as independent determinants of TNF-alpha (an inflammatory cytokine and adipocytokine) among Latino children. Future investigations should examine the potential roles of exercise, nutritional status, age, and growth hormone in explicating the relationship between TNF-alpha production and psychosocial distress and risk for infection among obese children.