The relationship between circulating estradiol and thyroid autoimmunity in males
The relationship between circulating estradiol and thyroid autoimmunity in males
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DOI：
10.1530/eje-13-0455
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发表时间：
2014-01-01
影响因子：
5.8
通讯作者：
Ongphiphadhanakul, Boonsong
中科院分区：
文献类型：
--
作者：
Chailurkit, La-or;Aekplakorn, Wichai;Ongphiphadhanakul, Boonsong
前言：虽然自身免疫性甲状腺疾病在男性中较少见，但雌激素是否与男性易感性的差异有关尚不清楚。目的：研究循环雌二醇(E-2)是否与男性甲状腺自身免疫有关。患者和方法：1,263名年龄在15-94岁的男性。结果：男性外周血E-2水平变化较大，范围为18.4~403.7 pmol/L，平均值为136.2/-51.7pmol/L，E-2随年龄增长而增加(r=0.18，P
Introduction: Although autoimmune thyroid disease is less common in males, it is unclear whether estrogen contributes to the difference in susceptibility among males.Objective: To examine whether circulating estradiol (E-2) is related to thyroid autoimmunity in males.Patients and methods: One-thousand two-hundred and sixty-three males aged 15-94 years were studied. Serum levels of E-2, TSH receptor antibody (TRAb), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), free thyroxine (FT4), and TSH were measured by ELISA.Results: Circulating E-2 varied widely in males, ranging 18.4-403.7 pmol/l with a mean value of 136.2 +/- 51.7 pmol/l. E-2 increased with age (r=0.18, P