Impairment of Immune Function in Harbor Seals (Phoca vitulina) Feeding on Fish from Polluted Waters

Impairment of Immune Function in Harbor Seals (Phoca vitulina) Feeding on Fish from Polluted Waters
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以污染水域中的鱼为食的斑海豹 (Phoca vitulina) 的免疫功能受损

DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
A. Osterhaus
A. Osterhaus
中科院分区：
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文献类型：
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作者：
R. L. Swart;P. Ross;L. Vedder;H. Timmerman;S. Heisterkamp;H. Loveren;J. Vos;P. Reijnders;A. Osterhaus

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在海豹和海豚中爆发高死亡率的疾病 最近吸引了相当多的公众和科学家 兴趣在大多数情况下，麻疹病毒感染是 被证明是疾病爆发的主要原因， 推测污染引起的免疫抑制发挥了作用：！ 贡献的角色。在这里，我们提出了一个前瞻性的结果， 半野外条件下的研究，其中两组港口 海豹（Phoca vitulina）被喂食来自海洋地区的鲱鱼， 污染程度不同;污染严重的波罗的海和 相对未受污染的大西洋。在93年期间， 周，监测免疫功能相关参数 并进行比较。我们发现， 增殖细胞活性和有丝分裂原诱导的增殖性T细胞应答 从波罗的海吃鲱鱼的海豹身上 明显更低。此外，我们还观察到， 在这些动物中循环的多形核粒细胞， 这可能表明细菌感染的发生率增加。 这是第一次证明免疫功能受损 与长期暴露于环境污染物有关的哺乳动物的功能 通过海洋食物积累的污染物 链
textabstractDisease outbreaks with high mortality rates among seals and dolphins have recently attracted considerable public and scientific interest. Allhouyh in most cases morbillivirus infections were shown to be the primary cause of the disease outbreaks, it was speculated that pollution-induced immunosuppression had playat:! a contributory role. Here we present results of a prospective study under semifield conditions, in which two groups of harbor seals (Phoca vitulina) were fed herring from marine regions with different contamination levels; the highly polluted Baltic Sea and the relatively unpolluted Atlantic Ocean. During a period of 93 weeks, parameters related to immune function were monitored and compared between the two groups. We found that natural killer-cell activity and mitogen-induced proliferative T -cell responses from the seals feeding on herring from the Baltic Sea were significantly lower. In addition, we observed higher levels of circulating polymorphonuclear granulocytes in these animals, which may indicate an increase in the occurrence of bacterial infections. This is the first demonstration of impaired immunological functions in mammals associated with chronic exposure to environmental contaminants accumulated through the marine food chain.