Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice
Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice
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DOI：
10.1016/j.etp.2010.12.009
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发表时间：
2012-09-01
影响因子：
--
通讯作者：
Unnikrishnan, M. K.
中科院分区：
文献类型：
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作者：
Bansal, Punit;Paul, Piya;Unnikrishnan, M. K.
本研究描述了小叶冷水花 (PM1) 富含黄酮类成分的抗糖尿病作用。 PM1 的 HPLC 表征表明存在多酚，即绿原酸、芦丁、木犀草素-7-O-葡萄糖苷、异火果苷、芹菜素-7-O-葡萄糖苷和槲皮素。 PM1 在体外抑制二肽基肽酶 IV (DPP-IV)，IC50 为 520.4 +/- 15.4 mu g/ml。 PM1，在腹腔注射剂量为 300、600 和 900 mg/kg 时，瘦小鼠的葡萄糖偏移 (AUC(0-120) (min)) 也分别产生剂量依赖性平均百分比降低 9.9、30.6 和 41.0。然而，即使是最高剂量的 PM1 也不会改变正常血糖状况。 PM1 剂量为 100 mg/kg/天，腹膜内注射28 天产生了显着的 (p
The present study describes the antidiabetic effect of the flavonoid rich fraction of Pilea microphylla (PM1). HPLC characterization of PM1 revealed the presence of polyphenols viz., chlorogenic acid, rutin, luteolin-7-O-glucoside, isorhoifolin, apigenin-7-O-glucoside, and quercetin. PM1 inhibited dipeptidyl peptidase IV (DPP-IV) in vitro with an IC50 of 520.4 +/- 15.4 mu g/ml. PM1, at doses of 300, 600 and 900 mg/kg i.p., also produced dose-dependent mean percent reductions of 9.9, 30.6 and 41.0 in glucose excursion (AUC(0-120) (min)) respectively in lean mice. However, even the highest dose of PM1 did not alter normoglycemic condition. PM1 at dose of 100 mg/kg/day, i.p. for 28 days produced significant (p