Does the hippocampus mediate objective binding or subjective remembering?
Does the hippocampus mediate objective binding or subjective remembering?
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DOI：
10.1016/j.neuroimage.2009.09.039
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发表时间：
2010-01-15
期刊：
影响因子：
5.7
通讯作者：
Slotnick, Scott D.
中科院分区：
文献类型：
--
作者：
Slotnick, Scott D.
人类功能性磁共振成像（fMRI）证据表明，海马体与情境记忆的关联程度高于项目记忆（只有情境记忆需要项目-情境结合）。一项单独的功能磁共振成像研究表明，海马体与“记忆”反应的关系比“知道”或基于熟悉的反应更大（在这些反应中，只有记忆反映了对特定细节的主观体验）。然而，之前的研究将情境记忆与记忆、项目记忆与认识混为一谈。本研究通过评估海马兴趣区（roi）内的活动，独立验证了海马功能的结合假说和记忆假说。在编码过程中，研究人员向参与者展示了彩色和灰色的抽象形状，并要求他们记住每个形状，以及它们是彩色的还是灰色的。在检索时，旧的和新的形状以灰色呈现，参与者将每个形状分类为“旧的和以前有颜色的”、“旧的和以前是灰色的”或“新的”，然后是“记住”或“知道”的反应。在11个海马区域中，有3个区域情境记忆的活动显著大于项目记忆，情境记忆-项目记忆通过“记得-知道”交互作用显著，情境记忆-项目记忆的活动显著大于项目记忆。这种活动模式只支持绑定假说。支持记忆假说的类似活动模式在海马体中从未被观察到。然而，一项有针对性的分析显示，在左侧顶叶下皮层有特定的记忆活动。目前的结果表明顶叶皮层可能与主观记忆有关，而海马体则介导结合。(C) 2009爱思唯尔公司版权所有。
Human functional magnetic resonance imaging (fMRI) evidence suggests the hippocampus is associated with context memory to a greater degree than item memory (where only context memory requires item-in-context binding). A separate line of fMRI research suggests the hippocampus is associated with "remember" responses to a greater degree than "know" or familiarity based responses (where only remembering reflects the subjective experience of specific detail). Previous studies, however, have confounded context memory with remembering and item memory with knowing. The present fMRI Study independently tested the binding hypothesis and remembering hypothesis of hippocampal function by evaluating activity within hippocampal regions-of-interest (ROIs). At encoding, participants were presented with colored and gray abstract shapes and instructed to remember each shape and whether it was colored or gray. At retrieval, old and new shapes were presented in gray and participants classified each shape as "old and previously colored", "old and previously gray", or "new", followed by a "remember" or "know" response. In 3 of 11 hippocampal ROIs, activity was significantly greater for context memory than item memory, the context memory-item memory by remember-know interaction was significant, and activity was significantly greater for context memory-knowing than item memory-remembering. This pattern of activity only supports the binding hypothesis. The analogous pattern of activity that Would have Supported the remembering hypothesis was never observed in the hippocampus. However, a targeted analysis revealed remembering specific activity in the left inferior parietal cortex. The present results suggest parietal cortex may be associated with subjective remembering while the hippocampus mediates binding. (C) 2009 Elsevier Inc. All rights reserved.