Keep Your Friends Close: Cell-Cell Contact and Skeletal Myogenesis
Keep Your Friends Close: Cell-Cell Contact and Skeletal Myogenesis
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DOI：
10.1101/cshperspect.a029298
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发表时间：
2017-02-01
影响因子：
7.2
通讯作者：
Goel, Aviva J.
中科院分区：
文献类型：
--
作者：
Krauss, Robert S.;Joseph, Giselle A.;Goel, Aviva J.
骨骼肌的发育是一个多阶段的过程，包括多能祖细胞的谱系承诺、成肌细胞分化和融合为多核肌纤维、肌纤维成熟为不同类型。谱系特异的转录调控是这一过程的核心，但肌肉发生也受到细胞外信号的调节。其中一些信号是由肌肉前体细胞之间的直接细胞-细胞接触或肌肉前体细胞与其他血统的细胞之间的直接细胞接触启动的。后者的例子包括迁移的神经脊细胞与多能肌祖细胞的相互作用，肌肉间质细胞与成肌细胞的相互作用，以及带有肌纤维的神经元的相互作用。其中涉及的信号因子包括Notch配体和受体、钙粘附素、Ig超家族成员，以及肾上腺素和Eph受体。在这篇文章中，我们描述了这一领域的最新进展，并强调了这些发现提出的公开问题。
Development of skeletal muscle is a multistage process that includes lineage commitment of multipotent progenitor cells, differentiation and fusion of myoblasts into multinucleated myofibers, and maturation of myofibers into distinct types. Lineage- specific transcriptional regulation lies at the core of this process, but myogenesis is also regulated by extracellular cues. Some of these cues are initiated by direct cell-cell contact between muscle precursor cells themselves or between muscle precursors and cells of other lineages. Examples of the latter include interaction of migrating neural crest cells with multipotent muscle progenitor cells, muscle interstitial cells with myoblasts, and neurons with myofibers. Among the signaling factors involved are Notch ligands and receptors, cadherins, Ig superfamily members, and Ephrins and Eph receptors. In this article we describe recent progress in this area and highlight open questions raised by the findings.