A 4-channel 3 Tesla phased array receive coil for awake rhesus monkey fMRI and diffusion MRI experiments.
A 4-channel 3 Tesla phased array receive coil for awake rhesus monkey fMRI and diffusion MRI experiments.
复制标题
DOI：
10.4236/jbise.2010.311141
复制
发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Khachaturian MH
中科院分区：
文献类型：
--
作者：
Khachaturian MH
觉醒猴功能磁共振成像和弥散磁共振成像结合传统的神经科学技术，有可能研究结构和功能神经网络。大多数猴子功能磁共振成像和扩散磁共振成像实验都是使用单个线圈进行的，这些线圈存在严重的EPI失真，从而限制了分辨率。通过构建用于猴子MRI研究的相控阵线圈，可以利用并行成像实现信噪比和解剖精度的提高(即减少EPI失真)。为猴子建造相控阵线圈的主要挑战是头部大小和空间限制的变化。在此，我们将相控阵技术应用于四通道相控阵线圈，能够提高全脑清醒猴fMRI和弥散磁共振实验的分辨率和图像质量。相控阵线圈能够适应不同的恒河猴头部大小(4-8岁)，并适合猴子立体定向设备提供的有限空间，结合并行成像提供初级视觉皮质的SNR增益和解剖精度，并将fMRI实验的分辨率提高2倍(1.25 mm至1.0 mm各向同性)，将扩散MRI实验的分辨率提高4倍(1.5 mm至0.9 mm各向同性)。
Awake monkey fMRI and diffusion MRI combined with conventional neuroscience techniques has the potential to study the structural and functional neural network. The majority of monkey fMRI and diffusion MRI experiments are performed with single coils which suffer from severe EPI distortions which limit resolution. By constructing phased array coils for monkey MRI studies, gains in SNR and anatomical accuracy (i.e., reduction of EPI distortions) can be achieved using parallel imaging. The major challenges associated with constructing phased array coils for monkeys are the variation in head size and space constraints. Here, we apply phased array technology to a 4-channel phased array coil capable of improving the resolution and image quality of full brain awake monkey fMRI and diffusion MRI experiments. The phased array coil is that can adapt to different rhesus monkey head sizes (ages 4–8) and fits in the limited space provided by monkey stereotactic equipment and provides SNR gains in primary visual cortex and anatomical accuracy in conjunction with parallel imaging and improves resolution in fMRI experiments by a factor of 2 (1.25 mm to 1.0 mm isotropic) and diffusion MRI experiments by a factor of 4 (1.5 mm to 0.9 mm isotropic).