Emotional impairment after right orbitofrontal lesion in a patient without cognitive deficits
Emotional impairment after right orbitofrontal lesion in a patient without cognitive deficits
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DOI：
10.1097/00001756-199906030-00021
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发表时间：
1999-06-03
期刊：
影响因子：
1.7
通讯作者：
Stegagno, L
中科院分区：
文献类型：
--
作者：
Angrilli, A;Palomba, D;Stegagno, L
本研究描述了一名患者M.L.，右眶额部病变，主要神经心理学测试（包括测量额叶功能的测试）显示无损伤。尽管如此，他还是深深地影响了情绪反应。与达马西奥的工作一致，患者在投射一组标准化的情绪幻灯片时皮肤电导较低。此外，他对不愉快的情绪表现出面部表情的改变，表现出低的皱眉肌电活动，与对不愉快刺激的回忆减少相关。在一项专注于情绪情境意象的任务中，M.L.的心率和皮肤电导反应在愉快和不愉快的条件下都受到影响。面部表情不愉快的图像脚本也受损。因此，眶额皮层被证明在检索心理生理情感模式，特别是不愉快的材料中发挥了关键作用。这些结果提供了第一个证据，眶额病变与情绪障碍在几个心理生理水平。NeuroReport 10：1741-1746（C）1999 Lippincott威廉姆斯& Wilkins.
THE present study describes a patient, M.L., with right orbitofrontal lesion, who showed no impairment on main neuropsychological tests, including those measuring frontal functions. Nevertheless, he had deeply affected emotional responses. In line with Damasio's work, the patient had lower skin conductance during the projection of a standardized set of emotional slides. Furthermore, he showed altered facial expressions to unpleasant emotions, displaying low corrugator supercilii electromyographical activity associated with reduced recall of unpleasant stimuli. During a task focusing on imagery of emotional situations, M.L.'s heart rate and skin conductance responses were affected during both pleasant and unpleasant conditions. Facial expressions to unpleasant imagery scripts were also impaired. Thus, the orbitofrontal cortex proved to play a critical role in retrieval of psychophysiological emotional patterns, particularly to unpleasant material. These results provide the first evidence that orbitofrontal lesions are associated with emotional impairment at several psychophysiological levels. NeuroReport 10:1741-1746 (C) 1999 Lippincott Williams & Wilkins.