A new discovery of STAT4 single nucleotide polymorphisms associated with hepatocellular carcinoma risk in Chinese Han population: a case-control study.
A new discovery of STAT4 single nucleotide polymorphisms associated with hepatocellular carcinoma risk in Chinese Han population: a case-control study.
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中国汉族人群中与肝癌风险相关的STAT4单核苷酸多态的新发现：一项病例对照研究。
DOI：
10.1042/bsr20210124
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发表时间：
2021-07-30
影响因子：
4
通讯作者：
Jiang C
中科院分区：
文献类型：
--
作者：
Chao X;Wu J;Zhang W;Feng X;Zhao L;Huang F;Jiang C
背景：肝细胞癌（HCC）是世界范围内常见的致命性恶性肿瘤。信号转导和转录激活因子4（STAT4）是全基因组关联研究确定的HCC易感基因。本研究的目的是确定 STAT4 基因中的四个候选单核苷酸多态性 (SNP) 与中国汉族人群中 HCC 风险之间的关联。方法：通过病例对照研究评估 1011 名中国汉族人群中 STAT4 SNP 与 HCC 风险之间的关联。 Agena MassARRAY 用于对 SNP 进行基因分型。通过逻辑回归分析评估不同遗传模型下SNP与HCC易感性之间的关联。多因素降维 (MDR) 分析了“SNP-SNP”在 HCC 风险中的相互作用。通过方差分析完成不同基因型之间临床特征的差异。结果：结果显示，在多种遗传模型下，STAT4 rs11889341与HCC风险显着相关（纯合子：比值比（OR）= 0.60，P=0.033；隐性：OR = 0.63，P=0.028；对数加法：OR = 0.83，P=0.032）。亚组分析结果显示，STAT4 rs11889341 与 55 岁以上、男性或吸烟参与者的 HCC 风险显着相关。 STAT4 rs7574865 和 rs10174238 均与年龄 > 55 岁、吸烟或饮酒的参与者的 HCC 风险显着相关。 STAT4单倍型（Trs11889341Trs7574865）可以降低肝癌的风险。此外，rs11889341和rs7574865与血清铁蛋白（SF）水平显着相关。结论：STAT4 rs11889341、rs7574865 或 rs10174238 可能与中国汉族人群的 HCC 风险相关。特别是，rs11889341 显示与 HCC 风险显着相关。
Background: Hepatocellular carcinoma (HCC) is a common fatal malignant tumor worldwide. Signal transducer and activator of transcription 4 (STAT4) is HCC susceptibility gene identified by genome-wide association study. The purpose of the present study was to determine the association between four candidate single nucleotide polymorphisms (SNPs) in STAT4 genes and HCC risk in Chinese Han population. Methods: A case–control study was conducted to assess the association between STAT4 SNPs and HCC risk in 1011 Chinese Han population. Agena MassARRAY was used to genotype SNPs. The association between SNPs and HCC susceptibility under different genetic models was evaluated by logistic regression analysis. Multifactorial dimension reduction (MDR) analyzed the interaction of ‘SNP–SNP’ in HCC risk. The difference of clinical characteristics between different genotypes was completed by ANOVA. Results: The results showed that STAT4 rs11889341 was significantly associated with HCC risk under multiple genetic models (homozygote: odds ratio (OR) = 0.60, P=0.033; recessive: OR = 0.63, P=0.028; log-additive: OR = 0.83, P=0.032). The results of subgroup analysis showed that STAT4 rs11889341 is significantly associated with HCC risk with participants who were >55 years, male or smoking. Both STAT4 rs7574865 and rs10174238 were significantly associated with HCC risk among participants who were >55 years, smoking or drinking. STAT4 haplotype (Trs11889341Trs7574865) could reduce the risk of HCC. In addition, rs11889341 and rs7574865 were significantly associated with the level of serum ferritin (SF). Conclusion: STAT4 rs11889341, rs7574865 or rs10174238 is potentially associated with HCC risk in Chinese Han population. In particular, rs11889341 showed outstanding association with HCC risk.
影响因子：
3.7
作者：
Uchino K;Tateishi R;Nakagomi R;Fujiwara N;Minami T;Sato M;Enooku K;Nakagawa H;Asaoka Y;Kondo Y;Shibahara J;Shiina S;Koike K
通讯作者：
Koike K