The Distribution Frequency of Interferon-Gamma Receptor 1 Gene Polymorphisms in Interferon-γ Release Assay-Positive Patients.
The Distribution Frequency of Interferon-Gamma Receptor 1 Gene Polymorphisms in Interferon-γ Release Assay-Positive Patients.
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干扰素γ受体1基因多态性在干扰素γ释放检测阳性患者中的分布频率
DOI：
10.1155/2017/4031671
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Dong Y
中科院分区：
文献类型：
--
作者：
Chen C;Chen L;Chen C;Chen Q;Zhao Q;Dong Y
Tuberculosis is caused by mycobacterium, a potentially fatal infectious bacterium. In recent years, TB cases increased in the whole world. WHO statistics data shows that the world's annual tuberculosis incidence was 8~10 million with about 3 million deaths. Several studies have shown that susceptibility to tuberculosis may be associated with IFNGR1 gene polymorphisms. Here, we report the distribution frequency of IFNGR1 gene polymorphisms in 103 cases of IGA-negative patients and 100 cases of IGA-positive patients from China by sequencing the IFNGR1 proximal ~750 bp promoter region. We found a total of 5 types of site mutations: -611 (G/A), -56 (T/C), -255 (C/T), -359 (T/C), and -72 (C/T). The two main types of gene polymorphisms among the IGA-negative and IGA-positive groups were -611 (G/A), with mutation rates of 88.3% and 78.4%, respectively, and -56 (T/C), with mutation rates of 84.5% and 83.8%, respectively, which had no statistical significance, and there was no correlation with the incidence of tuberculosis.
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影响因子：
3.2
作者：
Raviglione M;Sulis G
通讯作者：
Sulis G
影响因子：
5.8
作者：
Haverkamp, MH;van Dissel, JT;Holland, SM
通讯作者：
Holland, SM
DOI：
10.1164/rccm.200601-088oc
发表时间：
2006-08-01
影响因子：
24.7
作者：
Cooke, Graham S.;Campbell, Sarah J.;Hill, Adrian V. S.
通讯作者：
Hill, Adrian V. S.
影响因子：
3.3
作者：
Farnia, Poopak;Ghanavi, Jalaledin;Velayati, Ali Akbar
通讯作者：
Velayati, Ali Akbar
影响因子：
3.4
作者：
Shin, Joong-Gon;Park, Byung Lae;Shin, Hyoung Doo
通讯作者：
Shin, Hyoung Doo