Update on Juvenile Spondyloarthritis
Update on Juvenile Spondyloarthritis
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DOI：
10.1016/j.rdc.2013.06.002
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发表时间：
2013-11-01
影响因子：
2.3
通讯作者：
Colbert, Robert A.
中科院分区：
文献类型：
--
作者：
Ramanathan, Anusha;Srinivasalu, Hemalatha;Colbert, Robert A.
脊柱关节炎（SpA）包括一组由重叠的临床表现和遗传易感性联系在一起的疾病。为SpA成人开发的较新分类系统侧重于识别轴向或主要外周受累的个体。所有形式的SpA都可以在儿童时期开始，并且可以与成人疾病一起考虑。尽管如此，根据发病时的年龄，在表现和结局方面存在重要差异。本文强调了这些差异，已经了解到的遗传学和发病机制的SpA，以及重要的未满足的需求，为未来的研究。
Spondyloarthritis (SpA) encompasses a group of disorders linked by overlapping clinical manifestations and genetic predisposition. Newer classification systems developed for adults with SpA focus on identifying individuals with axial or predominantly peripheral involvement. All forms of SpA can begin during childhood, and can be considered on a continuum with adult disease. Nevertheless, there are important differences in presentation and outcome that depend on age at onset. This article highlights these differences, what has been learned about genetics and pathogenesis of SpA, and important unmet needs for future studies.