OBJECT EXPLORATION, HABITUATION, AND RESPONSE TO A SPATIAL CHANGE IN RATS FOLLOWING SEPTAL OR MEDIAL FRONTAL CORTICAL DAMAGE
OBJECT EXPLORATION, HABITUATION, AND RESPONSE TO A SPATIAL CHANGE IN RATS FOLLOWING SEPTAL OR MEDIAL FRONTAL CORTICAL DAMAGE
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DOI：
10.1037/0735-7044.103.5.1009
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发表时间：
1989-10-01
影响因子：
1.9
通讯作者：
POUCET, B
中科院分区：
文献类型：
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作者：
POUCET, B
在涉及物体探索、习惯化和对新奇事物的反应（通过空间变化后重新探索来测量）的实验中，对正常大鼠和患有中隔或内侧额叶皮层损伤的大鼠进行了比较。正常大鼠表现出高水平的初始探索活动，但随着时间的推移而减少。在空间变化之后，他们重新研究了移位的物体和未移位的物体。额叶动物的初始探索水平和习惯模式与正常受试者相似。然而，额叶大鼠仅重新探索移位的物体，而完全忽略未移位的物体。相反，隔膜大鼠表现出的行为模式与正常和额叶动物明显不同。隔膜大鼠的初始探索活动水平较低，随着时间的推移不会习惯，并且无法对移位或未移位的物体做出反应。这些结果表明，尽管隔海马复合体和内侧额叶皮层在空间组织行为中可能具有一些共同的功能，但这两种结构都有独特的作用。简要提及和讨论了有关间隔区或内侧额叶皮层可能的基本过程的一些假设。
Normal rats and rats sustaining septal or medial frontal cortex lesions were compared in experiments dealing with object exploration, habituation, and reaction to novelty (measured by renewed exploration following a spatial change). Normal rats exhibited high levels of initial exploratory activity which decreased over time. Following a spatial change, they reinvestiaged both the displaced object and the nondisplaced ones. Frontal animals were similar to normal subjects with respect to their initial exploratory level and habituation pattern. However, frontal rats reexplored only the displaced object and completely neglected the nondisplaced ones. In contrast, the behavioral pattern displayed by septal rats was markedly different from that of normal and frontal animals. Septal rats had lower levels of initial exploratory activity, did not habituate over time, and failed to react to either displaced or nondisplaced objects. These results show that although the septo-hippocampal complex and the medial frontal cortex may share some common function in spatially organized behaviours, both structures have unique roles. Some hypotheses about the possible basic processes subtended by the septal area or the medial frontal cortex are briefly mentioned and discussed.