Proliferation and differentiation characteristics of neural stem cells during course of cerebral cortical histogenesis.
Proliferation and differentiation characteristics of neural stem cells during course of cerebral cortical histogenesis.
复制标题
大脑皮质组织发生过程中神经干细胞的增殖和分化特征。
DOI：
10.1111/cga.12117
复制
发表时间：
2016
影响因子：
1.3
通讯作者：
Takahashi T.
中科院分区：
文献类型：
--
作者：
Mitsuhashi T;Takahashi T.
干细胞生物学研究领域的最新进展使得再生医学在包括中枢神经系统在内的身体各个系统中得以实现。然而，关于神经干细胞如何在哺乳动物中分裂和产生年轻神经元（尤其是在体内）的基础知识仍然不足。在本文中，我们将总结在小鼠大脑皮层中产生投射神经元的神经干细胞的细胞周期/分裂的概念。我们还将回顾调节与细胞周期调控机制相关的关键参数的分子机制，特别是细胞周期调控蛋白 p27Kip1，它是 G1 期细胞周期进展的抑制剂。对控制细胞周期进程的机制的更好理解有望有助于开发新策略，以提高体内和体外神经细胞/组织生产的效率。
Recent advancements in the research field of stem cell biology have enabled the realization of regenerative medicine in various systems of the body, including the central nervous system. However, fundamental knowledge regarding how neural stem cells divide and generate young neurons in mammals, especiallyin vivo, is still inadequate. In this article, we shall summarize the concept of cell cycle/division of neural stem cells that generate projection neurons in the murine cerebral cortex. We shall also review the molecular mechanisms that modulate the critical parameters related to the cell cycle regulatory mechanisms, with special reference to the cell cycle regulatory protein p27Kip1, an inhibitor of progression of the cell cycle at the G1 phase. A better understanding of the mechanisms controlling cell cycle progression is expected to contribute to the development of novel strategies to increase the efficiency of neural cell/tissue production, bothin vivoandin vitro.