Roles of palmitoylation in axon growth, degeneration and regeneration.
Roles of palmitoylation in axon growth, degeneration and regeneration.
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DOI：
10.1002/jnr.24003
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发表时间：
2017-08
影响因子：
4.2
通讯作者：
Thomas GM
中科院分区：
文献类型：
--
作者：
Holland SM;Thomas GM
蛋白脂修饰棕榈酰化在神经元中起着重要的作用，但目前关注最多的是这种修饰在成熟突触前和突触后的调节中的作用。然而，最近令人兴奋的发现表明，棕榈酰化对神经元轴突的生长和完整性也至关重要，并在传递轴突逆行和逆行信号中发挥着以前未被认识到的作用。在这里，我们回顾了棕榈酰化在调节轴突健康和疾病中的新作用。
The protein-lipid modification palmitoylation plays important roles in neurons, but most attention has focused on roles of this modification in the regulation of mature pre- and post-synapses. However, exciting recent findings suggest that palmitoylation is also critical for both the growth and integrity of neuronal axons and plays previously unappreciated roles in conveying axonal anterograde and retrograde signals. Here we review these emerging roles for palmitoylation in the regulation of axons in health and disease.