Animal models in translational studies of PTSD
Animal models in translational studies of PTSD
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DOI：
10.1016/j.psyneuen.2013.06.006
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发表时间：
2013-09-01
影响因子：
3.7
通讯作者：
Diamond, David M.
中科院分区：
文献类型：
--
作者：
Daskalakis, Nikolaos P.;Yehuda, Rachel;Diamond, David M.
了解创伤后应激障碍（PTSD）的神经生物学机制对于开发生物标志物和更有效的药物治疗至关重要。双向转化研究的设计解决创伤后应激障碍的各个方面是必要的。创伤后应激障碍的动物模型不仅需要捕捉创伤后应激障碍行为特征的复杂性，而且还需要通过实验来解决可能决定个体对创伤的脆弱性或恢复力的各种因素的影响，例如，遗传倾向、早年经历和社会支持。目前的审查涵盖了最近的翻译方法，以弥合人类和动物PTSD研究之间的差距，并建立一个框架，发现生物标志物和新的治疗方法。爱思唯尔有限公司出版
Understanding the neurobiological mechanisms of post-traumatic stress disorder (PTSD) is of vital importance for developing biomarkers and more effective pharmacotherapy for this disorder. The design of bidirectional translational studies addressing all facets of PTSD is needed. Animal models of PTSD are needed not only to capture the complexity of PTSD behavioral characteristics, but also to address experimentally the influence of variety of factors which might determine an individual's vulnerability or resilience to trauma, e.g., genetic predisposition, early-life experience and social support. The current review covers recent translational approaches to bridge the gap between human and animal PTSD research and to create a framework for discovery of biomarkers and novel therapeutics. Published by Elsevier Ltd.