Mechanisms and Management of Chronic Pain.
Mechanisms and Management of Chronic Pain.
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DOI：
10.3844/ijrnsp.2021.1.2
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发表时间：
2021
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慢性疼痛症状占所有医疗保健就诊的一半，折磨着>10%的美国成年人，在女性中的患病率更高，目前的镇痛药物在没有严重副作用的情况下很少提供足够的疗效。慢性疼痛也是国家阿片类药物健康危机的根本原因，这增加了医疗保健成本和死亡人数。因此，需要基于对伤害感受机制的详细理解的新疼痛疗法作为阿片类镇痛药的替代品，并且具有重要的社会意义。慢性疼痛是最普遍的人类健康问题之一，通常与认知和运动功能的伴随下降有关。疼痛与其他疾病密切相关，这些疾病可能缺乏对其病理学的认识。尽管可用药物成功减轻了疼痛，但大多数接受治疗的患者再次寻求专业帮助。疼痛症状发作和诊断之间的平均持续时间为几年，尽管大多数慢性疼痛患者每天都在遭受痛苦。尽管治疗许多与慢性疼痛相关的疾病给医疗保健带来了巨大的经济负担，但仍然无法获得有效和可靠的治疗干预。
Chronic pain symptoms account up to half of all health care visits, afflicts >10% of US adults, at a higher prevalence in women with current analgesic drugs rarely provide enough efficacy in the absence of serious side effects. Chronic pain is also the root cause of the national opioid health crisis, which adds to health care costs and deaths. Thus, new pain therapies based on detailed understanding of nociceptive mechanisms are needed as alternatives to opioid analgesics and are of great societal importance. Chronic pain is one of the most prevalent human health problems that often is associated by the concomitant decline in cognitive and motor functions. Pain is strongly associated with other diseases that can lack of awareness to its pathology. Despite a successful reduction of pain with available medications, majority of treated patients were seeking professional help again. The average time duration between the onset of pain symptoms and the diagnosis is couple of years despite the fact that majority of patients with chronic pain suffer every day. Efficacious and reliable therapeutic intervention is still unavailable despite the tremendous economic burden imposed on healthcare to treat many diseases associated with chronic pain.