Concurrent video-rate color and near-infrared fluorescence laparoscopy
Concurrent video-rate color and near-infrared fluorescence laparoscopy
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DOI：
10.1117/1.jbo.18.10.101302
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发表时间：
2013-10-01
影响因子：
3.5
通讯作者：
Ntziachristos, Vasilis
中科院分区：
文献类型：
--
作者：
Glatz, Juergen;Varga, Julia;Ntziachristos, Vasilis
由于肿瘤细胞与周围组织的光学对比度较低，因此肿瘤和肿瘤边缘的视觉识别和划分仍然具有挑战性。近年来，荧光分子成像在临床上被认为可以提高开放性手术中癌症的检测。本文通过描述一种能够同时记录彩色和近红外荧光图像和视频的新型视频速率成像腹腔镜，提出了荧光分子引导的下一步发展。视频速率运算是基于图形处理单元的图像处理。我们研究了该系统的光学特性，并提供了与术中内镜指导相关的性能指标，展示了人类疾病小鼠模型中肿瘤的幻影和内镜颜色和荧光分子成像。c 2013年中国光学仪器工程师学会（SPIE）
The visual identification and demarcation of tumors and tumor margins remains challenging due to the low optical contrast of cancer cells over surrounding tissues. Fluorescence molecular imaging was recently considered clinically for improving cancer detection during open surgery. We present herein a next step in the development of fluorescence molecular guidance by describing a novel video-rate imaging laparoscope capable of concurrently recording color and near-infrared fluorescence images and video. Video-rate operation is based on graphics processing unit-based image processing. We examine the optical characteristics of the system developed and provide performance metrics related to intra-operative endoscopic guidance, showcased on phantoms and endoscopic color and fluorescence molecular imaging of tumors in a mouse model of the human disease. c 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)