Threshold and distribution of afterdischarges with electrical cortical stimulation
Threshold and distribution of afterdischarges with electrical cortical stimulation
复制标题
皮层电刺激后放电的阈值和分布
DOI：
10.1016/j.jocn.2018.06.039
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发表时间：
2018
影响因子：
2
通讯作者：
Mikuni Nobuhiro
中科院分区：
文献类型：
--
作者：
Suzuki Hime;Enatsu Rei;Kanno Aya;Suzuki Yuto;Yokoyama Rintaro;Ookawa Satoshi;Ochi Satoko;Mikuni Nobuhiro
本研究的目的是调查的阈值和分布的后放电（AD）与皮层电刺激的功能brain mapping. Methods我们回顾性分析了数据，从11例难治性癫痫患者接受50-Hz皮层电刺激功能映射，然后切除。这些患者在六个多月内没有癫痫发作。结果额叶、颞叶、顶叶和枕叶AD的阈值分别为6 mA（2-15 mA）、8 mA（3-15 mA）、6 mA（2-15 mA）和6 mA（4-12 mA）。AD阈值无显著叶间差异。致痫灶内外无显著差异。AD的分布，在所有患者中观察到远程传播，反映额-顶-颞连接，以及连续传播。运动前区，顶下小叶，辅助运动区，和基底颞区的刺激出现在远程cortics.ConclusionWhile没有位置的差异，观察到在AD阈值，每个大脑区域显示了AD传播的特征模式。为了安全的功能映射，需要考虑远程AD扩展。
ObjectiveThe present study aimed to investigate the threshold and distribution of afterdischarges (ADs) with cortical electrical stimulation for functional brain mapping.MethodWe retrospectively analyzed data from 11 patients with medically intractable epilepsy who underwent 50-Hz cortical electrical stimulation for functional mapping followed by resection. These patients became seizure free for more than six months. The threshold and distribution of ADs induced by the stimulation were evaluated.ResultsThe median threshold was 6 mA (range: 2–15 mA) for the frontal lobe, 8 mA (3–15 mA) for the temporal lobe, 6 mA (2–15 mA) for the parietal lobe, and 6 mA (4–12 mA) for the occipital lobe. No significant interlobar differences were observed in AD thresholds. No significant differences were noted between within and outside epileptogenic zones. The distribution of ADs, remote spread was observed in all patients, reflecting fronto-parieto-temporal connections, as well as contiguous spread. The stimulation of premotor areas, the inferior parietal lobule, supplementary motor area, and basal temporal areas appeared to induce ADs in remote cortices.ConclusionWhile no locational differences were observed in AD thresholds, each brain region showed a characteristic pattern for AD spread. Remote AD spread needs to be considered for safe functional mapping.