Amiloride selectively blocks the low threshold (T) calcium channel.
Amiloride selectively blocks the low threshold (T) calcium channel.
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DOI：
10.1126/science.2451291
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发表时间：
1988-04
期刊：
影响因子：
56.9
通讯作者：
Cha-Min Tang;Fernando Presser;M. Morad
中科院分区：
文献类型：
--
作者：
Cha-Min Tang;Fernando Presser;M. Morad
在肌肉细胞和神经元中已发现不止一种电压门控钙通道。已报道了许多针对常规的、缓慢失活的高阈值（L）钙通道的特异性有机和无机阻断剂。但目前尚未发现低阈值（T）通道的特异性阻断剂。氨氯吡嗪脒，一种保钾利尿剂，现已表明能选择性阻断小鼠神经母细胞瘤和鸡背根神经节神经元中的低阈值钙通道。对T型钙通道的选择性阻断将有助于在不同组织中识别该通道，并确定其特定的生理作用。
More than one type of voltage-gated calcium channel has been identified in muscle cells and neurons. Many specific organic and inorganic blockers of the conventional, slowly inactivating high threshold (L) calcium channel have been reported. No specific blockers of the low threshold (T) channel have been as yet identified. Amiloride, a potassium sparing diuretic, has now been shown to selectively block the low threshold calcium channel in mouse neuroblastoma and chick dorsal root ganglion neurons. The selective blockade of the T-type calcium channel will allow identification of this channel in different tissues and characterization of its specific physiological role.