FRACTIONATED REGIMENS FOR STEREOTAXIC RADIOTHERAPY OF RECURRENT TUMORS IN THE BRAIN
FRACTIONATED REGIMENS FOR STEREOTAXIC RADIOTHERAPY OF RECURRENT TUMORS IN THE BRAIN
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DOI：
10.1016/0360-3016(91)90703-7
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发表时间：
1991-08-01
影响因子：
7
通讯作者：
HALL, EJ
中科院分区：
文献类型：
--
作者：
BRENNER, DJ;MARTEL, MK;HALL, EJ
放射外科（单次立体定向放射治疗）最初是为了治疗非恶性动静脉畸形而开发的，但人们对其用于治疗复发性脑肿瘤的兴趣越来越大。我们认为，有充分的理由期待改善结果的肿瘤放射治疗，在迟发效应方面，如果使用分次方案。目前，没有出版的指南可用于选择适当的剂量的分次方案。我们提出了两套指导方针，实验得出的放射生物学参数的基础上：首先，我们估计γ射线剂量，如果在不同数量的分数，应产生相当于70戈伊的I-125 X射线在低剂量率交付的早期效果，后者目前使用的RTOG间质近距离放射治疗试验。其次，我们估计剂量的多分割立体定向放射治疗，这可能是有利的替代方案，以特定剂量的单分割放射外科治疗。由于适当的硬件是可用的，分割立体定向放射治疗的使用值得认真考虑的治疗复发性脑肿瘤。
Radiosurgery (single-fraction stereotactic radiotherapy) was initially developed to treat non-malignant arteriovenous malformations, but there is growing interest in its use for the treatment of recurrent brain tumors. We suggest that there are sound reasons to expect improved results for tumor radiotherapy, in terms of late effects, if a fractionated regimen is used. At present, no published guidelines are available for choosing appropriate doses for fractionated regimens. We present two sets of guidelines, based on experimentally derived radiobiological parameters: first, we estimate gamma-ray doses which, if delivered in various numbers of fractions, should produce equivalent early effects to 70 Gy of I-125 X rays delivered at low dose rate; this latter regimen is currently used in RTOG interstitial brachytherapy trials. Second, we estimate doses for multi-fractioned stereotactic radiotherapy which may be advantageous alternatives to particular doses of single-fractioned radiosurgical therapy. As the appropriate hardware is available, the use of fractionated stereotactic radiotherapy deserves serious consideration for the treatment of recurrent tumors in the brain.