A Systematic Review of the Effect of Lifestyle Interventions on Adipose Tissue Gene Expression: Implications for Carcinogenesis
A Systematic Review of the Effect of Lifestyle Interventions on Adipose Tissue Gene Expression: Implications for Carcinogenesis
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DOI：
10.1002/oby.22010
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发表时间：
2017-11-01
期刊：
影响因子：
6.9
通讯作者：
Brenner, Darren R.
中科院分区：
文献类型：
--
作者：
Campbell, Kristin L.;Landells, Catherine E.;Brenner, Darren R.
目的：体重和身体活动水平与多种类型癌症之间的联系机制尚未得到很好的理解。本综述的目的是研究生活方式干预对人类脂肪组织水平上生活方式和癌症风险的生物标志物的影响。研究方法：使用与运动或饮食干预、脂肪组织生物学和关注结局相关的关键词检索Embase、MEDLINE和CINAHL。符合条件的研究包括与对照或其他干预措施相比的人体运动和/或饮食干预措施的随机临床试验，报告了皮下腹部脂肪组织的收集。结果：19项研究符合纳入标准。八项研究改变了饮食摄入量，五项改变了运动水平，六项研究将两者结合起来。皮下脂肪组织基因表达的变化最常见于饮食减肥，瘦素、肿瘤坏死因子α和白细胞介素6减少，沿着脂联素增加。仅运动干预或研究组的变化有限。结论：导致体重减轻的干预导致皮下脂肪组织中脂肪因子和炎症标志物的基因表达改变，而单独运动的基因表达变化较小。
Objective: The mechanisms driving the associations between body weight and physical activity levels and multiple types of cancer are not yet well understood. The purpose of this review was to examine the effects of lifestyle interventions on proposed biomarkers of lifestyle and cancer risk at the level of adipose tissue in humans. Methods: Embase, MEDLINE, and CINAHL were searched by using keywords relating to exercise or diet interventions, adipose tissue biology, and outcomes of interest. Eligible studies included randomized clinical trials of exercise and/ or dietary interventions in humans compared with control or other interventions, reporting the collection of subcutaneous abdominal adipose tissue. Results: Nineteen studies met criteria for inclusion. Eight studies modified dietary intake, five altered exercise levels, and six studies used a combination of both. Change in subcutaneous adipose tissue gene expression was most commonly observed with dietary weight loss, with a pattern of decrease in leptin, tumor necrosis factor alpha, and interleukin 6, along with an increase in adiponectin. There was limited change with exercise-only interventions or study arms. Conclusions: Interventions leading to weight loss result in an altered gene expression of adipokines and inflammatory markers in subcutaneous adipose tissue, while less change in gene expression was noted with exercise alone.