Obesity and the role of adipose tissue in inflammation and metabolism
Obesity and the role of adipose tissue in inflammation and metabolism
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DOI：
10.1093/ajcn/83.2.461s
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发表时间：
2006-02-01
影响因子：
7.1
通讯作者：
Obin, MS
中科院分区：
文献类型：
--
作者：
Martin, ASG;Obin, MS
最近的发现，尤其是对荷尔蒙瘦素和脂联素的发现，修正了脂肪细胞只是身体能量储存库的概念。相反，脂肪细胞也是内分泌器官，在调节全身生理方面具有多种代谢作用。瘦人的小脂肪细胞促进代谢动态平衡；肥胖者增大的脂肪细胞招募巨噬细胞，促进炎症和一系列易发生胰岛素抵抗的因素的释放。运动激活肌肉和其他组织中的AMP激活的蛋白激酶(AMPK)，这是一条增加脂肪氧化和葡萄糖运输的途径。重要的是，脂肪细胞荷尔蒙瘦素和脂联素也激活AMPK；值得注意的是，同样的途径也被某些抗糖尿病药物激活，如噻唑烷二酮类。越来越多地，我们对脂肪细胞作为内分泌器官的理解正在导致对肥胖和健康的新见解。
Recent discoveries, notably of the hormones leptin and adiponectin, have revised the notion that adipocytes are simply a storage depot for body energy. Instead, adipocytes are also endocrine organs, with multiple metabolic roles in regulating whole-body physiology. Small adipocytes in lean individuals promote metabolic homeostasis; the enlarged adipocytes of obese individuals recruit macrophages and promote inflammation and the release of a range of factors that predispose toward insulin resistance. Exercise activates the AMP-activated protein kinase (AMPK) in muscle and other tissues, a pathway that increases fat oxidation and glucose transport. Importantly, the adipocyte hormones leptin and adiponectin also activate AMPK; remarkably, the same pathway is activated by certain antidiabetic agents such as thiazolidinediones. Increasingly, our understanding of the adipocyte as an endocrine organ is leading to new insights into obesity and health.