Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins.
Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins.
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DOI：
10.1039/c2cc38016a
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发表时间：
2013-01
影响因子：
4.9
通讯作者：
Takumi Yamaguchi;Tsuyoshi Uno;Yoshinori Uekusa;M. Yagi-Utsumi;Koichi Kato
中科院分区：
文献类型：
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作者：
Takumi Yamaguchi;Tsuyoshi Uno;Yoshinori Uekusa;M. Yagi-Utsumi;Koichi Kato
我们成功地展示了一系列的神经节苷脂的小bicelles与一个统一的限制大小，提供纳米级标准化的膜模拟物的光谱特性之间的神经节苷脂簇和淀粉样蛋白形成的弱遭遇复合物。这使得能够通过NMR光谱探测α-突触核蛋白作为治疗靶点的初始膜着陆过程。
We successfully displayed a series of gangliosides on small bicelles with a uniform confined size, offering nanoscale standardized membrane mimics for spectroscopic characterization of weak encounter complexes formed between ganglioside clusters and amyloidogenic proteins. This enabled probing of initial membrane-landing processes of α-synuclein as a therapeutic target by NMR spectroscopy.