Micronutrient deficiencies in early pregnancy are common, concurrent, and vary by season among rural nepali pregnant women
Micronutrient deficiencies in early pregnancy are common, concurrent, and vary by season among rural nepali pregnant women
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DOI：
10.1093/jn/135.5.1106
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发表时间：
2005-05-01
影响因子：
4.2
通讯作者：
West, KP
中科院分区：
文献类型：
--
作者：
Jiang, TN;Christian, P;West, KP
发展中国家的孕妇易患多种微量营养素缺乏症。我们调查了他们的患病率和季节性变化的一部分，在人口为基础的基线评估，产妇微量营养素补充试验在尼泊尔东南部农村平原进行。11种微量营养素的血清浓度进行了评估，在1165名孕妇在第一个三个月前补充。使用定义的截止值，维生素A，E和D缺乏的患病率分别为7%，25%和14%。近33%的妇女缺乏核黄素，40%和28%的妇女分别缺乏血清维生素B-6和B-12。只有12%的妇女缺乏叶酸，但61%的妇女缺乏锌。低血清铁浓度的患病率为40%，33%为贫血（血红蛋白< 110 g/L）。孕妇普遍缺乏多种微量营养素。超过10%的孕妇既贫血又缺乏B族复合维生素，而22%的妇女既贫血又缺锌。只有4%的女性没有缺陷，而20%的女性有2，3或4个缺陷。几乎18%的妇女有≥ 5种缺陷。营养素状况因季节而异;一般在冬季最好，但血清维生素D浓度在炎热的夏季和季风月份达到峰值。南亚农村妇女在怀孕开始时可能会出现多种微量营养素缺乏症，这种情况可能因富含微量营养素的食物供应的季节性而异。
Pregnant women in developing countries are vulnerable to multiple micronutrient deficiencies. We investigated their prevalence and seasonal variation as part of a baseline assessment in a population-based, maternal micronutrient supplementation trial conducted in the rural Southeastern plains of Nepal. Serum concentrations of 11 micronutrients were assessed in 1165 pregnant women in the 1st trimester before supplementation. Using defined cutoff values, the prevalence of deficiencies of vitamins A, E, and D were 7, 25, and 14%, respectively. Nearly 33% of the women were deficient in riboflavin, and 40 and 28% had serum vitamin B-6 and B-12 deficiencies, respectively. Only 12% of the women were folate deficient, but 61% were zinc deficient. The prevalence of low serum iron concentration was 40%, and 33% were anemic (hemoglobin < 110 g/L). Multiple micronutrient deficiencies were common among pregnant women. Over 10% of the pregnant women were both anemic and deficient in B-complex vitamins, whereas 22% of women were both anemic and zinc deficient. Only 4% of women had no deficiency, whereas similar to 20% of the women had 2, 3, or 4 deficiencies. Almost 18% of women had >= 5 deficiencies. Micronutrient status varied by season; it was generally best during the winter months, except for serum vitamin D concentration, which peaked during the hot summer and monsoon months. Women in rural South Asia are likely to begin a pregnancy with multiple micronutrient deficiencies that may vary with seasonality in micronutrient-rich food availability.