Autonomous early detection of eye disease in childhood photographs
Autonomous early detection of eye disease in childhood photographs
复制标题
DOI：
10.1126/sciadv.aax6363
复制
发表时间：
2019-10-01
期刊：
影响因子：
13.6
通讯作者：
Shaw, Bryan F.
中科院分区：
文献类型：
--
作者：
Munson, Micheal C.;Plewman, Devon L.;Shaw, Bryan F.
“红色反射试验”用于在标准儿科检查中筛查儿童白瞳（“白色眼”），但在检测许多眼部疾病方面无效。白瞳症也出现在随意的照片中。临床实用性的筛选照片白瞳症是未报告的。在这里，设计了一个免费的智能手机应用程序（CRADLE：计算机辅助白瞳检测器）来检测摄影白瞳，并以“白色眼睛检测器”的名称下载。“这项研究通过回顾性分析52，982张儿童纵向照片来确定CRADLE的敏感性，特异性和准确性，这些照片是由父母在参加这项研究之前收集的。该队列包括20名患有视网膜母细胞瘤、Coats病、白内障、弱视或远视的儿童和20名对照儿童。对于80%患有眼部疾病的儿童，应用程序在诊断前1.3年拍摄的照片中检测到白瞳（95%置信区间，0.4至2.3年）。CRADLE应用程序允许父母通过摄影增强临床白瞳筛查。
The "red reflex test" is used to screen children for leukocoria ("white eye") in a standard pediatric examination, but is ineffective at detecting many eye disorders. Leukocoria also presents in casual photographs. The clinical utility of screening photographs for leukocoria is unreported. Here, a free smartphone application (CRADLE: ComputeR-Assisted Detector of LEukocoria) was engineered to detect photographic leukocoria and is available for download under the name "White Eye Detector." This study determined the sensitivity, specificity, and accuracy of CRADLE by retrospectively analyzing 52,982 longitudinal photographs of children, collected by parents before enrollment in this study. The cohort included 20 children with retinoblastoma, Coats' disease, cataract, amblyopia, or hyperopia and 20 control children. For 80% of children with eye disorders, the application detected leukocoria in photographs taken before diagnosis by 1.3 years (95% confidence interval, 0.4 to 2.3 years). The CRADLE application allows parents to augment clinical leukocoria screening with photography.