Use of HIV protease inhibitors is associated with left ventricular morphologic changes and diastolic dysfunction
Use of HIV protease inhibitors is associated with left ventricular morphologic changes and diastolic dysfunction
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DOI：
10.1097/01.qai.0000017995.56638.f8
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发表时间：
2002-07-01
期刊：
影响因子：
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通讯作者：
Lai, SH
中科院分区：
文献类型：
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作者：
Meng, QY;Lima, JAC;Lai, SH
HIV蛋白酶抑制剂（PI）治疗可能与心脏和血管并发症有关。我们评估了PI对心脏功能和结构的影响。对98例年龄在25 ~ 45岁之间、接受抗逆转录病毒治疗的HIV感染的黑人成年人进行M型、横断面和多普勒超声心动图检查。45例（56.1%）患者使用PI（PI平均使用持续时间：用途：29.6 +/- 12.2个月）。PI组与非PI组的左室收缩功能和心脏瓣膜返流无显著性差异。接受PI的患者室间隔厚度显著更高（1.1 +/-0.3 vs 1.0 +/- 0.2 cm; p = 0.049）。LV后壁厚度（1.1 +/- 0.2 vs. 1.0 +/- 0.2; p = 0.027），早期峰值速度（E波）与晚期峰值速度（A波）的比值（E/A比值）（1.36 +/- 0.30 vs. 1.53 +/- 0.31; p = 0.023）低于未接受PIS的患者。直线回归分析显示，后壁厚度、间隔厚度。左房内径、左室质量和E/A比值与PI治疗的对数转换持续时间显著相关。尽管已证实PI对HIV感染患者的益处，但本报告表明，在HIV感染患者的心脏结构和功能分析中，应了解并考虑持续PI摄入与LV肥大之间的相关性。
HIV protease inhibitor (PI) therapy may be associated With cardiac and vascular complications. We assessed the effects of PIs on cardiac function and structure. M-mode, cross-sectional, and Doppler echocardiography were performed in 98 consecutive black adults aged 25 to 45 years with HIV infection who were receiving antiretroviral therapy. Forty-five (56.1%) took, PIs (mean duration of PI use: 29.6 +/- 12.2 months). No significant differences between the PI and non-PI groups Were found in left ventricular (LV) systolic function and cardiac valve regurgitation. Those who took PIs had a significantly higher interventricular septum thickness 1.1 +/- 03 vs. 1.0 +/- 0.2 cm; p = .049). LV posterior Wall thickness (1.1 +/- 0.2 vs. 1.0 +/- 0.2; p = .027), and lower ratio of early peak velocity (E wave) to late peak velocity (A wave) (E/A ratio) (1.36 +/- 0.30 vs. 1.53 +/- 0.31; p = .023) than did those Who did not take PIS. Linear regression analyses indicated that posterior wall thickness, septum thickness. left atrial dimension, LV mass, and E/A ratios were significantly associated With the log-transformed duration of PI therapy. Despite the proven benefits of PIs in patients with HIV infection, this report demonstrates an association between continued PI intake and LV hypertrophy that should be known and taken into consideration in the analysis of cardiac structure and function in patients with HIV infection.