Allelic variants interaction of clock gene and g-protein β3 subunit gene with diurnal preference
Allelic variants interaction of clock gene and g-protein β3 subunit gene with diurnal preference
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DOI：
10.1080/07420520701534632
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发表时间：
2007-01-01
影响因子：
2.8
通讯作者：
Kim, Leen
中科院分区：
文献类型：
--
作者：
Lee, Heon-Jeong;Paik, Jong-Woo;Kim, Leen
据报道，CLOCK基因的3111 C/T单核苷酸多态性（SNP）和G蛋白63亚基基因（GNB 3）的825 C/T SNP影响昼夜偏好。本研究试图描述健康韩国大学生中CLOCK基因和GNB 3多态性与昼夜偏好之间的关联。所有受试者完成了13项早晨综合量表（CSM）。CLOCK基因中3111 C/T SNP和GNB 3基因中825 C/T SNP之间的相互作用显著影响昼夜偏好，根据CSM性能分项评分（F = 10.94，p = 0.001）。然而，当独立分析这两个基因的不同多态性时，没有检测到与昼夜偏好的直接相关性。CLOCK基因3111 C/T SNP和GNB 3基因825 C/T SNP表现出影响昼夜偏好性的基因-基因交互作用。
The 3111 C/T single nucleotide polymorphism (SNP) in the CLOCK gene and the 825C/T SNP in the G-protein 63 subunit gene (GNB3) have been reported to Influence diurnal preference. This study has attempted to characterize the association between the CLOCK gene and GNB3 polymorphisms and diurnal preference in healthy Korean college students. All subjects completed the 13-item Composite Scale for Morningness (CSM). The interaction between the 3111 C/T SNP in the CLOCK gene and the 825 C/T SNP in the GNB3 gene significantly influenced diurnal preference, according to the CSM Performance subscore (F = 10.94, p = 0.001). However, when the different polymorphisms of the two genes were analyzed independently, no direct correlations with diurnal preference were detected. The CLOCK gene 3111 C/T SNP and GNB3 gene 825 C/T SNP were found to manifest a gene-gene interaction that affects diurnal preference.