Long-term Outcomes of Cataract Surgery in Patients with Retinitis Pigmentosa
Long-term Outcomes of Cataract Surgery in Patients with Retinitis Pigmentosa
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DOI：
10.1016/j.oret.2021.12.010
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发表时间：
2022-04-04
影响因子：
4.5
通讯作者：
Sonoda, Koh-Hei
中科院分区：
文献类型：
--
作者：
Nakamura, Shun;Fujiwara, Kohta;Sonoda, Koh-Hei
目的：目的：探讨视网膜色素变性（RP）患者行白内障手术的长期疗效。设计：回顾性观察研究。参与者：64例典型RP患者（22名男子，42名妇女;平均年龄，2007年5月至2015年10月期间在九州大学医院接受白内障手术的62.8 +/- 10.1岁），随访>=方法：采用中央10-2程序，对术前和术后的视功能，包括最佳矫正视力（BCVA）和Humphrey视野分析仪（HFA）检查参数进行比较。根据OCT检查结果将术前黄斑中心凹椭圆区（EZ）的情况分为3级（1级：不可见; 2级：异常; 3级：正常）。主要结果：BCVA，HFA 10-2测试中的视网膜敏感度。平均术前BCVA为0.64 +/- 0.52最小分辨角对数（logMAR），最终术后BCVA为0.61 +/- 0.67 logMAR（P = 0.57）。术后最佳矫正视力仅在保留中心凹EZ（3级）的患眼有显著提高（P < 0.01）。在45名患者的62只眼睛中，进行了HFA 10-2测试，最终访视时的偏差、黄斑敏感度和中心凹敏感度的平均值与术前值相比显著降低3级眼术后视力无明显变化（P> 0.01）结论：RP患者白内障术后长期病程中，随着病情进展，许多患者出现视力下降。保留中心凹EZ的术前发现与较好的视力预后相关，表明EZ评估可用于预测RP患者白内障手术的长期视力结局。(C)2021年美国眼科学会
Purpose: To investigate the long-term outcomes of cataract surgery in patients with retinitis pigmentosa (RP).Design: Retrospective, observational study.Participants: Sixty-four patients with typical RP (22 men, 42 women; average age, 62.8 +/- 10.1 years) who underwent cataract surgery at Kyushu University Hospital between May 2007 and October 2015 and were followed up for >= 3 years after the surgery.Methods: Differences between presurgery and postsurgery visual function, including best-corrected visual acuity (BCVA) and parameters in the Humphrey field analyzer (HFA) examination using the central 10-2 program, were investigated. The presurgery conditions of the foveal ellipsoid zone (EZ) were classified into 3 grades (grade 1: invisible; grade 2: abnormal; grade 3: normal) based on OCT findings.Main Outcome Measures: BCVA, the retinal sensitivity in the HFA 10-2 test.Results: Cataract surgery was performed in 96 eyes, with an average follow-up period of 5.8 +/- 2.4 years. The mean presurgery BCVA was 0.64 +/- 0.52 logarithm of the minimum angle of resolution (logMAR), and the final postsurgery BCVA was 0.61 +/- 0.67 logMAR (P = 0.57). Significant improvement in the postsurgery BCVA was observed only in eyes with preserved foveal EZ (grade 3) (P < 0.01). In 62 eyes of 45 patients who underwent the HFA 10-2 test, the mean values of deviation, macular sensitivity, and foveal sensitivity at the final visit were significantly decreased compared with preoperative values (P < 0.01), whereas those in grade 3 eyes did not change significantly after the surgery (P = 0.13).Conclusions: In the long-term course after cataract surgery in patients with RP, many patients experienced vision loss with progression of the disease. The preoperative finding of preserved foveal EZ was associated with a better visual prognosis, suggesting that EZ evaluation is useful for predicting the long-term visual outcome of cataract surgery in patients with RP. (C) 2021 by the American Academy of Ophthalmology