The signaling role of a mitochondrial superoxide burst during stress.
The signaling role of a mitochondrial superoxide burst during stress.
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DOI：
10.4161/psb.22749
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发表时间：
2013-01
影响因子：
2.9
通讯作者：
Vanlerberghe GC
中科院分区：
文献类型：
--
作者：
Cvetkovska M;Alber NA;Vanlerberghe GC
植物线粒体被认为在生物胁迫下的防御反应和非生物胁迫下的驯化反应中起着信号传导器的作用。然而，由线粒体产生并由细胞解释的主要信号在很大程度上是未知的。最近，我们发现线粒体在特定的植物与病原体相互作用中产生持续的超氧化物（O2-）爆发。这种O2爆发似乎是由影响细胞器内O2生成和清除速率的线粒体成分控制的。O2-爆发似乎影响下游过程，如超敏反应，表明它可能代表一个重要的线粒体信号，支持植物的胁迫反应。这些发现产生了许多有趣的问题，如产生O2爆发所需的上游因素，支持和平行于这种爆发的线粒体事件，以及响应这种爆发的下游事件。
Plant mitochondria are proposed to act as signaling organelles in the orchestration of defense responses to biotic stress and acclimation responses to abiotic stress. However, the primary signal(s) being generated by mitochondria and then interpreted by the cell are largely unknown. Recently, we showed that mitochondria generate a sustained burst of superoxide (O2-) during particular plant-pathogen interactions. This O2- burst appears to be controlled by mitochondrial components that influence rates of O2- generation and scavenging within the organelle. The O2- burst appears to influence downstream processes such as the hypersensitive response, indicating that it could represent an important mitochondrial signal in support of plant stress responses. The findings generate many interesting questions regarding the upstream factors required to generate the O2- burst, the mitochondrial events that occur in support of and in parallel with this burst and the downstream events that respond to this burst.