Mortality risk comparing walking pace to handgrip strength and a healthy lifestyle: A UK Biobank study
Mortality risk comparing walking pace to handgrip strength and a healthy lifestyle: A UK Biobank study
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DOI：
10.1177/2047487319885041
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发表时间：
2019-11-12
影响因子：
8.3
通讯作者：
Yates, Thomas
中科院分区：
文献类型：
--
作者：
Zaccardi, Francesco;Franks, Paul W.;Yates, Thomas
快走和更强的肌肉力量与更长的寿命有关。然而，这些关联是否受到其他生活方式行为的影响却鲜为人知。方法 在基线时收集 450,888 名英国生物银行研究参与者的日常步行速度（自定义为慢速、稳定/平均或轻快）、测力计评估的握力、生活方式行为（体力活动、看电视、饮食、饮酒、睡眠和吸烟）和体重指数等信息。我们评估了不同步行速度和握力水平的个人和综合生活方式行为以及体重指数的 10 年标准化生存率。结果 在中位随访 7.0 年的时间里，女性死亡人数为 3808 人（1.6%），男性死亡人数为 6783 人（3.2%）。无论吸烟以外的其他生活方式行为的参与程度如何，快步行者比慢步行者具有生存优势。与采取健康生活方式的慢步行者相比，在其他方面采取不健康生活方式的快步行者的估计 10 年生存率更高：女性为 97.1%（95% 置信区间：96.9-97.3） vs 95.0%（94.6-95.4）；男性为 94.8% (94.7-95.0) vs 93.7% (93.3-94.2)。体重指数改变了男性步行速度与生存之间的关联，在体重不足的参与者中观察到快走的生存益处最大。与步行速度相比，握力的不同生活方式行为的 10 年生存率有更多重叠。结论 除吸烟外，生活方式不健康的快步行者比生活方式健康的慢步行者的死亡率更低。
Aims Brisk walking and a greater muscle strength have been associated with a longer life; whether these associations are influenced by other lifestyle behaviours, however, is less well known. Methods Information on usual walking pace (self-defined as slow, steady/average, or brisk), dynamometer-assessed handgrip strength, lifestyle behaviours (physical activity, TV viewing, diet, alcohol intake, sleep and smoking) and body mass index was collected at baseline in 450,888 UK Biobank study participants. We estimated 10-year standardised survival for individual and combined lifestyle behaviours and body mass index across levels of walking pace and handgrip strength. Results Over a median follow-up of 7.0 years, 3808 (1.6%) deaths in women and 6783 (3.2%) in men occurred. Brisk walkers had a survival advantage over slow walkers, irrespective of the degree of engagement in other lifestyle behaviours, except for smoking. Estimated 10-year survival was higher in brisk walkers who otherwise engaged in an unhealthy lifestyle compared to slow walkers who engaged in an otherwise healthy lifestyle: 97.1% (95% confidence interval: 96.9-97.3) vs 95.0% (94.6-95.4) in women; 94.8% (94.7-95.0) vs 93.7% (93.3-94.2) in men. Body mass index modified the association between walking pace and survival in men, with the largest survival benefits of brisk walking observed in underweight participants. Compared to walking pace, for handgrip strength there was more overlap in 10-year survival across lifestyle behaviours. Conclusion Except for smoking, brisk walkers with an otherwise unhealthy lifestyle have a lower mortality risk than slow walkers with an otherwise healthy lifestyle.