The Adherence to Bone by Cytoplasmic Elements of Osteoclasts
The Adherence to Bone by Cytoplasmic Elements of Osteoclasts
复制标题
破骨细胞细胞质成分对骨的粘附
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
J. E. Horton
中科院分区：
文献类型：
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作者：
Mark I. Ryder;S. D. Jenkins;J. E. Horton
破骨细胞和骨之间的密切联系表明，这些细胞可能附着在骨表面。在施加生物物理诱导的细胞分离力后，我们在甲状旁腺激素刺激的骨移植中研究了这种细胞-表面关系。用透射电子显微镜检查破骨细胞附近的骨表面是否存在残留的细胞膜成分。这项研究的结果为破骨细胞与骨表面的粘连提供了证据，并暗示透明带和褶皱边界的元素是细胞-膜结合的部位。
The intimate association observed between osteoclasts and bone has suggested that these cells may be adherent to the bony surface. We investigated this cell-surface relationship in parathyroid hormone-stimulated bone explants following applications of biophysically-induced cell detachment forces. Bone surfaces adjacent to disrupted osteoclasts were examined with transmission electron microscopy for the presence of residual cell membrane elements. Results of this study provide evidence for the adherence of osteoclasts to bony surfaces and implicate elements of both clear zone and ruffled border as cell-membrane bonded sites.