Selective Serotonin Reuptake Inhibitor Fluoxetine Inhibits Replication of Human Enteroviruses B and D by Targeting Viral Protein 2C
Selective Serotonin Reuptake Inhibitor Fluoxetine Inhibits Replication of Human Enteroviruses B and D by Targeting Viral Protein 2C
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DOI：
10.1128/aac.02084-12
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发表时间：
2013-04-01
影响因子：
4.9
通讯作者：
van Kuppeveld, Frank J. M.
中科院分区：
文献类型：
--
作者：
Ulferts, Rachel;van der Linden, Lonneke;van Kuppeveld, Frank J. M.
虽然肠道病毒属含有许多重要的人类病原体，但目前还没有获得许可的治疗或预防肠道病毒感染的药物。我们报道了选择性5-羟色胺再摄取抑制剂氟西汀(Prozac)抑制人类肠道病毒B(HEV-B)和HEV-D的复制，但不影响HEV-A和HEV-C或人鼻病毒A或B的复制。我们发现氟西汀干扰病毒RNA的复制，我们确定病毒蛋白2C是该化合物的靶标。
Although the genus Enterovirus contains many important human pathogens, there is no licensed drug for either the treatment or the prophylaxis of enterovirus infections. We report that fluoxetine (Prozac)-a selective serotonin reuptake inhibitor-inhibits the replication of human enterovirus B (HEV-B) and HEV-D but does not affect the replication of HEV-A and HEV-C or human rhinovirus A or B. We show that fluoxetine interferes with viral RNA replication, and we identified viral protein 2C as the target of this compound.