Multifunctional Cu(39)S(28) Hollow Nanopeanuts for In Vivo Targeted Photothermal Chemotherapy.
Multifunctional Cu(39)S(28) Hollow Nanopeanuts for In Vivo Targeted Photothermal Chemotherapy.
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用于体内靶向光热化疗的多功能Cu39S28空心纳米花生
DOI：
10.1039/c7tb01086a
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发表时间：
2017-09-07
期刊：
影响因子：
--
通讯作者：
Han G
中科院分区：
文献类型：
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作者：
Li L;Yang X;Hu X;Lu Y;Wang L;Peng M;Xia H;Yin Q;Zhang Y;Han G
主动靶向的中空纳米粒可能在精确的抗癌治疗中发挥关键作用。本文采用一步法合成了独特的Cu39S28中空纳米粒子，并对其形成机理进行了阐述。所合成的Cu39S28 HNPs具有良好的光热转换效率(41.1%)和药物存储容量(DOX，99.5%)。同时，DOX载药纳米复合材料对pH值和近红外线(NIR)都表现出了很高的释药敏感性。特别是，叶酸(FA)可以很容易地与合成的Cu39S28 HNPs偶联，而不需要进一步修饰，从而获得靶向的效果。FA修饰的Cu39S28 HNPs在体外表现出有效的靶向作用，在体内可显著提高肿瘤靶向作用10倍以上。此外，在808 nm激光作用下，Cu39S28 HNPs在体内外的综合热疗和药物释放较单纯的光热或化疗效果显著提高。主要脏器的组织学研究也证明了良好的生物相容性，但由于纳米复合材料的堆积和联合光热化疗的作用，肿瘤部位遭到严重破坏。因此，多功能纳米复合材料对乳腺癌具有良好的治疗效果，是一种优良的抗肿瘤药物。本工作提出了一种一步直接水相合成Cu39S28中空纳米粒子的方法，用于超灵敏肿瘤靶向光热化疗。
Actively targeted hollow nanoparticles may play key roles in precise anti-cancer therapy. Here, unique Cu39S28 hollow nanopeanuts (HNPs) were synthesized via a facile one-step method and the formation mechanism was illustrated. The as-synthesized Cu39S28 HNPs exhibit outstanding photothermal conversion efficiency (41.1%) and drug storage capacity (DOX, 99.5 %). At the same time, the DOX drug loading nanocomposites have shown great sensitive response of release to either pH value or near infrared ray (NIR). In particular, the folic acid (FA) can easily conjugate with the synthesized Cu39S28 HNPs without further modification to get a targeted effect. The FA modified Cu39S28 HNPs showed an efficiently targeting effect in vitro and could considerably enhance the tumor-targeting effect more than 10 times in vivo. Moreover, the synthetical hyperthermia and drug release from Cu39S28 HNPs when under 808 nm laser could significantly improve the therapeutic efficacy compared with photothermal or chemotherapy alone both in vitro and in vivo. The histological studies in main organs also proved the well biocompatibility, while the tumor sites were in seriously destruction due to the accumulation of the nanocomposites and the combined photothermal chemo therapy effect. Therefore, the multi-functional nanocomposites is excellent antitumor agents due to their superb therapy effect in breast cancer. This work represents a one-step directly aqueous method to synthesize Cu39S28 hollow nanopeanuts towards ultrasensitive tumor targeted photothermal chemotherapy.