Inhibition of Helicobacter pylori motility by (+)-syringaresinol from unripe Japanese apricot
Inhibition of Helicobacter pylori motility by (+)-syringaresinol from unripe Japanese apricot
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DOI：
10.1248/bpb.29.172
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发表时间：
2006-01-01
影响因子：
2
通讯作者：
Tatematsu, M
中科院分区：
文献类型：
--
作者：
Miyazawa, M;Utsunomiya, H;Tatematsu, M
未成熟日本杏的甲醇提取物显示出抑制幽门螺杆菌运动的活性。分离得到抑制性化合物1，经光谱分析鉴定为（+）-阿铃加树脂酚（1）。（+）-丁香树脂酚（1）抑制H. pylori运动，并且IC 50值为50 μ g/ml。
A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited > 90% of the H. pylori motility at a concentration of 500 mu g/ml and the IC50 value was 50 mu g/ml.