Heterogeneity of bone mineral density and fatigue failure of human vertebrae.
Heterogeneity of bone mineral density and fatigue failure of human vertebrae.
复制标题
骨矿物质密度的异质性和人体椎骨的疲劳衰竭。
DOI：
10.1016/j.jbiomech.2013.02.015
复制
发表时间：
2013
影响因子：
2.4
通讯作者：
Flynn,MichaelJ
中科院分区：
文献类型：
--
作者：
Yeni,YenerN;Poisson,LailaM;Flynn,MichaelJ
利用骨组织特性的异质性来预测骨折风险的研究越来越受到关注。定量计算机断层扫描（QCT）测量的体积骨矿物质密度（BMD）的异质性特别令人感兴趣，因为这些测量在临床上是可行的。以往对人体椎骨骨密度异质性与力学行为关系的研究仅考虑了准静态强度，样本数量有限。McCubbrey等人（1995）研究了局部BMD预测椎骨疲劳寿命的价值，根据短周期试验确定，力水平与椎骨的估计强度成比例，但该工作的重点是最佳预测子组，而没有特别关注BMD的异质性或关系的正负方向。之前的分析也没有考虑疲劳寿命数据的删失性质。因此，BMD异质性是否与疲劳寿命正相关或负相关，以及这是否独立于平均或最小BMD尚不清楚。在目前的工作中，我们重新访问的McCubbrey数据的BMD异质性和疲劳寿命之间的关系进行了初步检查，使用生存分析。分析表明，BMD异质性测量为椎体内BMD的标准差，在椎骨与短周期（高振幅）疲劳寿命的平均BMD独立呈负相关。这些结果激发了对骨密度异质性在人体椎骨疲劳失效和临床骨折风险中的作用的进一步研究。
There is increasing interest in using the heterogeneity of tissue properties in a bone for predicting its fracture risk. Heterogeneity of volumetric bone mineral density (BMD) as measured from quantitative computed tomography (QCT) is of particular interest as these measurements are clinically feasible. Previous examinations of the relationship between the BMD heterogeneity and the mechanical behavior of human vertebrae only considered quasistatic strength and were with limited number of samples. McCubbrey et al. (1995) studied the value of regional BMDs for predicting vertebral fatigue life, determined from short-cycle tests at force levels scaled with the estimated strength of the vertebra, but the focus of that work was in best predictor subsets without a specific focus on the heterogeneity of BMD or the positive vs negative direction of the relationships. The previous analysis also did not take into account the censored nature of the fatigue life data. As such, whether BMD heterogeneity is positively or negatively associated with fatigue life and whether this is independent of the average or minimum BMD are not clear. In the present work, we revisited the McCubbrey data for a preliminary examination of the relationship between BMD heterogeneity and fatigue life using survival analysis. The analysis suggests that BMD heterogeneity measured as the intra-vertebral standard deviation of BMDs in a vertebra is negatively associated with short cycle (high-amplitude) fatigue life independent of the average BMD. The results motivate further studies on the role of BMD heterogeneity in fatigue failure and clinical fracture risk of human vertebrae.