Progress in Environmental Mutagenesis
Progress in Environmental Mutagenesis
复制标题
环境诱变研究进展
DOI：
10.1038/bjc.1981.62
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发表时间：
1981
影响因子：
8.8
通讯作者：
M. Fox
中科院分区：
文献类型：
--
作者：
M. Fox
本卷是1979年在南斯拉夫举行的第9届EEMS年会上提交的论文集，涵盖诱变（化学与辐射）遗传变化的分子机制和工业经验和测试的比较方面。前两部分包含一些有趣的简短评论论文，对于希望更新这一领域知识的人来说，这些论文将是有用的，而不必过于详细地查看广泛的文献。其中几项审查表明，目前在这一领域的重点转移，即试图了解启动和促进机制，而不仅仅是积累数据。也许更有趣的是评价短期试验的一般更关键的方法，例如Matter（Sandoz）的贡献，他指出了一个不受欢迎的事实，即随着越来越多的“敏感”短期体外试验的开发，在高等生物中证实这些结果将变得越来越困难，因为诱变/致癌作用很可能被毒性作用掩盖。即，将产生越来越多的“假阳性”。他还警告说，不要过于普遍地接受正式的相关性，他说，例如，“有可能找到一个正式的相关性之间，男性的工资和离婚率。“总的来说，这是一本有趣的论文集，但其中大部分信息以前都曾在类似的会议论文集上发表过，大约20英镑的价格似乎很贵。
This volume is a collection ofpapers presented at the 9th Annual EEMS meeting in Yugoslavia in 1979, covering comparative aspects of mutagenesis (chemical vs radiation) molecular mechanisms of genetic change and industrial experience and testing. The first 2 sections contain some interesting short review papers which will be of use to people wishing to update their knowledge in this field without a too detailed look at the extensive literature. Several of these reviews indicate the current shift of emphasis in this field; i.e. an attempt to understand mechanisms of both initiation and promotion rather than the mere accumulation of data. More interesting perhaps is the generally more critical approach to evaluation of shoit-term tests, exemplified by the contribution fiom Matter (Sandoz) who points out the not w%videly appreciated fact that as more and more 'sensitive" short-term in vitro tests are developed, it wvill become increasingly difficult to confirm these results in higher organisms, as mutagenic/carcinogenic effects may well be masked by toxic effects, i.e. more and more 'false positives" will be produced. He also warns against the too general acceptance of formal correlations by stating that, e.g. 'It would be possible to find a formal correlation betw,veen salaries of elergymen and the divorce rate." Overall, an interesting collection of papers, but much of the information has been previously published in similar conference proceedings and at around £20 the volume seems expensive.