Dopamine receptors modulate sodium excretion in denervated kidney.
Dopamine receptors modulate sodium excretion in denervated kidney.
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多巴胺受体调节去神经支配肾脏中的钠排泄。
DOI：
10.1152/ajprenal.1986.250.6.f1033
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Eisner,GM
中科院分区：
文献类型：
--
作者：
Jose,PA;Felder,RA;Holloway,RR;Eisner,GM
多巴胺（DA）通过受神经支配的肾脏调节钠排泄。为了研究DA在去神经支配（DNX）肾脏中的作用，研究了DA 1/DA 2拮抗剂顺式氟哌噻吨（cis-flupenthixol）（第2组，n = 7）在急性单侧DNX后，在生理盐水负荷的Wistar-Kyoto大鼠中静脉内给予（10 nmol × kg-1 × min-1）（组1，n = 7）和接受2.5 nmol X kg-1 X min-1的DA 1拮抗剂SCH 23390的组（组3，n = 7）。采用戊巴比妥钠麻醉。通过DNX肾中的尿钠排泄和肾去甲肾上腺素含量的降低以及受神经支配的右肾中的抗心房尿来评估DNX的排泄。安慰剂组的平均动脉压略有下降（第1组，106.7 +/- 2.2 vs 99.3 +/- 2.4 mmHg）以及顺式氟噻吨后（第2组，108.8 +/- 2.7 vs. 92.8 +/- 1.8 mmHg），但SCH 23390给药后未发生（第3组，105.6 +/- 1.6 vs. 103 +/- 1.1 mmHg）。安慰剂或SCH 23390对DNX或神经支配肾脏的肾小球滤过率没有影响，但在DNX肾脏中给予顺式氟哌噻吨后，肾小球滤过率略有下降。给药后的钠和水排泄量在各组之间存在差异。在DNX肾中，仅第2组尿流量减少，而钠排泄分数则略有下降，SCH 23390（P <0.05配对t检验）（3.53 +/- 0.34 vs. 2.89 +/- 0.20%）与顺式氟噻吨显著相关（3.18 +/- 0.50 vs. 1.21 +/- 0.18%），安慰剂组无变化（3.25 +/- 0.61 vs. 3.45 +/- 0.45%）。（250字处删节）
Dopamine (DA) modulates sodium excretion by the innervated kidney. To examine the role of DA in the denervated (DNX) kidney the effects of the DA1/DA2 antagonist cis-flupenthixol (group 2, n = 7) (10 nmol X kg-1 X min-1), given intravenously in saline-loaded Wistar-Kyoto rats after acute unilateral left DNX, were compared with a placebo group (group 1, n = 7) and a group that received the DA1 antagonist SCH 23390 (group 3, n = 7) at 2.5 nmol X kg-1 X min-1. Pentobarbital sodium anesthesia was employed. Adequacy of DNX was assessed by a natriuresis and decrease in renal norepinephrine content in the DNX kidney and an antinatriuresis in the innervated right kidney. Mean arterial pressure slightly decreased in the placebo group (group 1, 106.7 +/- 2.2 vs. 99.3 +/- 2.4 mmHg) and after cis-flupenthixol (group 2, 108.8 +/- 2.7 vs. 92.8 +/- 1.8 mmHg) but not after SCH 23390 (group 3, 105.6 +/- 1.6 vs. 103 +/- 1.1 mmHg). Glomerular filtration rate was not affected by placebo or SCH 23390 in the DNX or innervated kidney but did slightly decrease after cis-flupenthixol in the DNX kidney. Sodium and water excretion after drug administration differed among the groups. In the DNX kidney urine flow decreased only in group 2, whereas fractional sodium excretion decreased modestly (P less than 0.05 paired t test) with SCH 23390 (3.53 +/- 0.34 vs. 2.89 +/- 0.20%) markedly with cis-flupenthixol (3.18 +/- 0.50 vs. 1.21 +/- 0.18%) and was unchanged in the placebo group (3.25 +/- 0.61 vs. 3.45 +/- 0.45%).(ABSTRACT TRUNCATED AT 250 WORDS)