Reduced Functional Coupling in the Default-Mode Network During Self-Referential Processing
Reduced Functional Coupling in the Default-Mode Network During Self-Referential Processing
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DOI：
10.1002/hbm.20920
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发表时间：
2010-08-01
影响因子：
4.8
通讯作者：
Vink, Matthijs
中科院分区：
文献类型：
--
作者：
van Buuren, Mariet;Gladwin, Thomas E.;Vink, Matthijs
默认模式网络（DMN）中的活动被认为与自我参照处理有关，比如思考一个人的偏好或人格特征。虽然DMN通常被认为是一个网络，但越来越多的证据表明，DMN的每个区域都专门用于自我参照处理的不同子功能。在这里，我们通过研究DMN区域之间在自我参照处理过程中的耦合变化来解决功能专门化的问题。为此，研究人员在一项任务中评估了大脑活动，在这项任务中，受试者必须指出一个特征形容词是否描述了他们自己的个性（自我参照，自我条件），另一个人的个性（他人参照，其他条件），或者该特征是否符合社会要求（非参照，控制条件）。为了排除心肺过程对活动和功能耦合的混杂影响，我们对这些影响的fMRI信号进行了校正。DMN区域内的活动被发现是由自我参照加工调节的。更具体地说，与“他者”和“对照组”相比，在“自我”条件下，前额叶内侧皮层背侧、前额叶内侧皮层腹侧和后扣带皮层的活动增加了。此外，与其他和控制条件相比，自我条件下DMN区域之间的耦合减少，而DMN区域与网络外区域之间的耦合增加。因此，这些结果为DMN内的功能专门化提供了指示，并支持DMN的每个区域都涉及自指处理的不同子功能的概念。中国生物医学工程学报（英文版），2010。(C) 2010 Wiley-Liss, Inc。
Activity within the default-mode network (DMN) is thought to be related to self-referential processing, such as thinking about one's preferences or personality traits. Although the DMN is generally considered to function as a network, evidence is starting to accumulate that suggests that areas of the DMN are each specialized for different subfunctions of self-referential processing. Here, we address the issue of functional specialization by investigating changes in coupling between areas of the DMN during self-referential processing. To this aim, brain activity was assessed during a task in which subjects had to indicate whether a trait adjective described their own personality (self-referential, Self condition), that of another person (other-referential, Other condition), or whether the trait was socially desirable (nonreferential, Control condition). To exclude confounding effects of cardiorespiratory processes on activity and functional coupling, we corrected the fMRI signal for these effects. Activity within areas of the DMN was found to be modulated by self-referential processing. More specifically, during the Self condition compared to the Other and Control condition, activity within the dorsal medial prefrontal cortex, ventral medial prefrontal cortex, and posterior cingulate cortex was increased. Moreover, coupling between areas of the DMN was reduced during the Self condition compared to the Other and Control condition, while coupling between regions of the DMN and regions outside the network was increased. As such, these results provide an indication for functional specialization within the DMN and support the notion that each area of the DMN is involved in different subfunctions of self-referential processing. Hum Brain Mapp 31:7117-1127, 2010. (C) 2010 Wiley-Liss, Inc.