Investigation of Resolution Effects Using a Specialized Diffusion Tensor Phantom
Investigation of Resolution Effects Using a Specialized Diffusion Tensor Phantom
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DOI：
10.1002/mrm.24774
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发表时间：
2014-03-01
影响因子：
3.3
通讯作者：
Laun, Frederik B.
中科院分区：
文献类型：
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作者：
Bach, Michael;Fritzsche, Klaus H.;Laun, Frederik B.
目的：由于穹窿、扣带回等脑结构在精神疾病中的重要作用，基于弥散成像的脑精细结构分析具有很高的临床潜力。然而，在精细结构中的扩散参数的量化是特别容易的部分体积效应（PVEs）。MethodsIn这项研究中，一个幻影的调查PVEs及其对扩散参数的影响，在不同直径的精细结构。体模是通过将湿聚酯纤维缠绕到锭子上而制成的。得到的纤维束具有良好的定义的正方形横截面的1- 25毫米（2），并提供了一个均匀的和高的分数各向异性（FA约为0.9）。结果表明，推断的结果，如纤维的几何形状和扩散参数强烈依赖于感兴趣的结构的体素网格的相对位置。PVES后处理方法，如基于轨道的空间统计和纤维tractography.ConclusionThese结果表明，PVES在常见的后处理任务的处理可能是有问题的，提出的幻影提供了一个有价值的工具，这些效果的改善和评估。Magn Reson Med 71：1108-1116，2014。(c)2013 Wiley Periodicals，Inc.
PurposeThe clinical potential of the diffusion imaging-based analysis of fine brain structures such as fornix or cingulum is high due to the central role of these structures in psychiatric diseases. However, the quantification of diffusion parameters in fine structures is especially prone to partial volume effects (PVEs).MethodsIn this study, a phantom for the investigation of PVEs and their influence on diffusion parameters in fine structures of different diameter is presented. The phantom is produced by winding wet polyester fibers onto a spindle. The resulting fiber strands have well defined square cross-sections of 1-25mm(2) and provide a homogeneous and high fractional anisotropy (FA approximate to 0.9).ResultsSeveral PVEs are demonstrated and analyzed. It is shown that inferred results such as the fiber geometry and diffusion parameters strongly depend on the relative position of the structure of interest to the voxel-grid. Several implications of PVEs on post-processing methods such as Tract-based Spatial Statistics and fiber tractography are demonstrated.ConclusionThese results show that the handling of PVEs in common post-processing tasks can be problematic, and that the presented phantom provides a valuable tool for the improvement and evaluation of these effects. Magn Reson Med 71:1108-1116, 2014. (c) 2013 Wiley Periodicals, Inc.