Perfusion CT can predict the response to chemoradiation therapy and survival in esophageal squamous cell carcinoma: initial clinical results.
Perfusion CT can predict the response to chemoradiation therapy and survival in esophageal squamous cell carcinoma: initial clinical results.
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DOI：
10.3892/or.18.4.901
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发表时间：
2007-10
期刊：
影响因子：
4.2
通讯作者：
K. Hayano;S. Okazumi;K. Shuto;H. Matsubara;H. Shimada;Y. Nabeya;T. Kazama;N. Yanagawa;T. Ochiai
中科院分区：
文献类型：
--
作者：
K. Hayano;S. Okazumi;K. Shuto;H. Matsubara;H. Shimada;Y. Nabeya;T. Kazama;N. Yanagawa;T. Ochiai
通过增强CT预测放化疗(CRT)疗效的能力将对食管鳞癌的治疗有价值。本研究的目的是评价CT灌注成像对食管鳞癌患者CRT疗效的预测价值。连续31例食管鳞癌患者在CRT前行CT灌注扫描。我们回顾了血流参数与CRT疗效之间的相关性。比较临床病理指标和血流量对生存率的影响。临床应答者21人，无应答者10人。临床应答者CRT前血流量显著高于无应答者(P=0.0004)，CRT前血容量显著高于无应答者(P=0.03)，CRT前平均通过时间显著短于无应答者(P=0.002)。对于CRT前血流，当临界点设定为50ml/100g/min时，对临床应答者的检测准确率为90.3%。高血流肿瘤患者的生存期明显长于低血流肿瘤患者(P=0.006)。多因素分析显示血流是影响预后的显著独立因素(P=0.01)。因此，灌注CT可能有助于确定哪些晚期食管鳞癌患者将受益于CRT。
The ability to predict the response to chemoradiation therapy (CRT) by contrast-enhanced CT would be valuable for managing esophageal squamous cell carcinoma. The purpose of this study was to evaluate the usefulness of Perfusion CT to predict the response to CRT in patients with esophageal squamous cell carcinoma. Thirty-one consecutive patients with esophageal squamous cell carcinoma underwent Perfusion CT before CRT. We retrospectively investigated the correlations between Perfusion parameters and the response to CRT. Clinicopathological markers and blood flow were compared in terms of survival. There were 21 clinical responders and 10 non-responders. Clinical responders showed significantly higher pre-CRT blood flow (P=0.0004), significantly higher pre-CRT blood volume (P=0.03) and a significantly shorter pre-CRT mean transit time (P=0.002) than non-responders. For pre-CRT blood flow, accuracy was 90.3% for detection of clinical responders when the cut-off point was set at 50 ml/100 g/min. Patients with high blood flow tumors survived significantly longer than those with low blood flow tumors (P=0.006). Multivariate analysis identified blood flow as a significant independent prognostic factor (P=0.01). Therefore, Perfusion CT may help to identify patients with advanced esophageal squamous cell carcinoma who will benefit from CRT.