Optimization of a secondary VOI protocol for lung imaging in a clinical CT scanner.
Optimization of a secondary VOI protocol for lung imaging in a clinical CT scanner.
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DOI：
10.1002/acm2.12354
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发表时间：
2018-07
影响因子：
2.1
通讯作者：
Wen H
中科院分区：
文献类型：
--
作者：
Larsen TC;Gopalakrishnan V;Yao J;Nguyen CP;Chen MY;Moss J;Wen H
我们提出了一种解决方案，以满足未满足的临床需求，即在患者仍在扫描仪中时，通过初次（筛查）胸部CT显示肺结节或肺囊肿边缘的原位“近距离观察”。我们首先评估了当前全身CT扫描仪用于高分辨率筛查扫描的可用选项，包括主要扫描数据和HRCT的ROI重建，但发现它们在肺组织中的SNR不足或切片覆盖不连续。在当前临床CT系统的能力范围内，我们选择了二次感兴趣体积（VOI）方案的解决方案，其中辐射剂量聚焦到感兴趣z位置的短束轴向扫描中，并结合感兴趣xy位置的小FOV重建。这项工作的目的是设计一种VOI方案，该方案针对临床全身CT系统中的靶向肺部成像进行了优化。使用包含模拟囊肿的仿肺泡沫插入物的胸部体模，我们确定了适当的扫描模式，并优化了扫描和重建参数。与标准胸部CT相比，VOI方案在仿肺泡沫中产生的纹理振幅噪声比为3.2倍，仿肺泡沫与参考泡沫之间的纹理差异为8.4倍。它改善了模拟囊肿壁的细节，并在线对插入中提高了分辨率。次级VOI方案的有效剂量平均为42%，在VOI定位相对于标准胸部CT的最差情况下高达100%。优化后的方案将用于获得肺部病变的详细CT纹理，这些纹理是肺部疾病类型和阶段的生物标志物。
We present a solution to meet an unmet clinical need of an in‐situ “close look” at a pulmonary nodule or at the margins of a pulmonary cyst revealed by a primary (screening) chest CT while the patient is still in the scanner. We first evaluated options available on current whole‐body CT scanners for high resolution screening scans, including ROI reconstruction of the primary scan data and HRCT, but found them to have insufficient SNR in lung tissue or discontinuous slice coverage. Within the capabilities of current clinical CT systems, we opted for the solution of a secondary, volume‐of‐interest (VOI) protocol where the radiation dose is focused into a short‐beam axial scan at the z position of interest, combined with a small‐FOV reconstruction at the xy position of interest. The objective of this work was to design a VOI protocol that is optimized for targeted lung imaging in a clinical whole‐body CT system. Using a chest phantom containing a lung‐mimicking foam insert with a simulated cyst, we identified the appropriate scan mode and optimized both the scan and recon parameters. The VOI protocol yielded 3.2 times the texture amplitude‐to‐noise ratio in the lung‐mimicking foam when compared to the standard chest CT, and 8.4 times the texture difference between the lung mimicking and reference foams. It improved details of the wall of the simulated cyst and better resolution in a line‐pair insert. The Effective Dose of the secondary VOI protocol was 42% on average and up to 100% in the worst‐case scenario of VOI positioning relative to the standard chest CT. The optimized protocol will be used to obtain detailed CT textures of pulmonary lesions, which are biomarkers for the type and stage of lung diseases.
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影响因子：
3.8
作者：
Kemerink, GJ;Kruize, HH;vanEngelshoven, JMA
通讯作者：
vanEngelshoven, JMA
影响因子：
3.9
作者：
Neculaes, Vasile Bogdan;Edic, Peter M.;De Man, Bruno
通讯作者：
De Man, Bruno
影响因子：
5
作者：
Christner, Jodie A.;Kofler, James M.;McCollough, Cynthia H.
通讯作者：
McCollough, Cynthia H.
影响因子：
2.1
作者：
Lee J;Kim JS;Cho S
通讯作者：
Cho S
影响因子：
3.8
作者：
Kemerink, GJ;Kruize, HH;Lamers, RJS
通讯作者：
Lamers, RJS