Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI) -: Mechanistic insights from serial contrast-enhanced magnetic resonance imaging
Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI) -: Mechanistic insights from serial contrast-enhanced magnetic resonance imaging
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DOI：
10.1161/01.cir.0000095788.78169.af
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发表时间：
2003-11-04
期刊：
影响因子：
37.8
通讯作者：
Zeiher, AM
中科院分区：
文献类型：
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作者：
Britten, MB;Abolmaali, ND;Zeiher, AM
背景-实验和初步临床研究表明，移植循环血（CPC）或骨髓来源（BMC）祖细胞可能有益于影响急性心肌梗死（AMI）后的梗死后重构过程。为了将输注细胞的功能特征与4个月随访结果的定量测量相关联，我们进行了连续对比增强MRI，并在冠状动脉内输注前立即评估了移植祖细胞的迁移能力。方法和结果在28例AMI后4.7+/-1.7天接受BMCs或CPC进入梗死动脉的再灌注AMI患者中，最初和4个月后进行的系列对比增强MRI显示总体射血分数显著增加（从44+/-10%至49+/-10%; P=0.003），收缩末期容积减少（从69+/-26至60+/-28 mL; P=0.003），舒张末期容积不变（122+/-34 vs 117+/-37 mL; P=NS）。晚期增强（LE）体积测量的CT大小从46+/-32降至37+/-28 mL（P
Background-Experimental and initial clinical studies suggest that transplantation of circulating blood-(CPC) or bone marrow-derived (BMC) progenitor cells may beneficially affect postinfarction remodeling processes after acute myocardial infarction (AMI). To relate functional characteristics of the infused cells to quantitative measures of outcome at 4-month follow-up, we performed serial contrast-enhanced MRI and assessed the migratory capacity of the transplanted progenitor cells immediately before intracoronary infusion.Methods and Results-In 28 patients with reperfused AMI receiving either BMCs or CPCs into the infarct artery 4.7+/-1.7 days after AMI, serial contrast-enhanced MRI performed initially and after 4 months revealed a significant increase in global ejection fraction (from 44+/-10% to 49+/-10%; P=0.003), a decrease in end-systolic volume (from 69+/-26 to 60+/-28 mL; P=0.003), and unchanged end-diastolic volumes (122+/-34 versus 117+/-37 mL; P=NS). Infarct size, measured as late enhancement (LE) volume, decreased significantly, from 46+/-32 to 37+/-28 mL (P